№ 3 (184) 2023 р. С. 76–83

ЦУКРОВИЙ ДІАБЕТ 2-ГО ТИПУ: ЕПІДЕМІОЛОГІЯ, УСКЛАДНЕННЯ ТА РАННЯ ДІАГНОСТИКА

Одеський національний медичний університет, Одеса, Україна

DOI 10.32782/2226-2008-2023-3-14

У статті проаналізовано сучасні дані щодо захворюваності на цукровий діабет 2-го типу (ЦД 2 типу). Цукровий діабет залишається одним із найпоширеніших захворювань у світі та значно погіршує якість життя, супроводжується розвитком ускладнень, ранньою інвалідизацією і передчасною летальністю. Наведено статистичні дані за останні роки стосовно поширеності хвороби у світі. Показано зв’язок між наявністю цукрового діабету та розвитком тяжких ускладнень. Так, діабет призводить до розвитку серцево-судинних, цереброваскулярних ускладнень, є причиною термінальної ниркової недостатності, сліпоти, анемії, підвищує ризик ампутації нижніх кінцівок і багатьох інших уражень. Застосування скринінг-тестів дозволяє своєчасно виявити людей, які належать до груп високого ризику розвитку ЦД 2 типу, та рано діагностувати безсимптомний діабет, що попереджає виникнення тяжких ускладнень і поліпшує прогноз та якість життя пацієнтів.

Ключові слова: цукровий діабет, поширеність захворювання, діабетичні ускладнення, рання діагностика.

REFERENCES

  1. IDF Diabetes Atlas. 10th edition. 2021; Available from: https://diabetesatlas.org/.
  2. Heald AH, Stedman M, Davies M et al. Estimating life years lost to diabetes: outcomes from analysis of National Diabetes Audit and Office of National Statistics data. Cardiovasc Endocrinol Metab. 2020; 9:183–185.
  3. Hong Sun, Pouya Saeedi, Suvi Karuranga et al. IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Research and Clinical Practice. 2022; 183. Available from: https:// doi.org/10.1016/j.diabres.2021.109119.
  4. Ogurtsova K, Guariguata L, Barengo NC et al. IDF Diabetes Atlas: Global estimates of undiagnosed diabetes in adults for 2021. Diabetes Research and Clinical Practice. 2022; 183: 109118. Available from: https://doi.org/10.1016/j. diabres.2021.109118.
  5. Bommer Сh, Sagalova V, Heesemann E et al. Global Economic Burden of Diabetes in Adults: Projections From 2015 to 2030. Diabetes Care. 2018; 41: 963–970. Available from: https://doi.org/10.2337/dc17-1962.
  6. Marcellusi A, Viti R, Sciattella P et al. Economic aspects in the management of diabetes in Italy. BMJ Open Diabetes Res Care. 2016; 4(1): 000197 DOI: 10.1136/bmjdrc-2016-000197.
  7. Public Health Center of the Ministry of Health of Ukraine. Available from: https://phc.org.ua/kontrol-zakhvoryuvan/ neinfekciyni-zakhvoryuvannya.
  8. Khyts A. School of endocrinologist: modern injection therapy of diabetes. Ukrainian Medical Journal. 2020; 1/1(135): 58–60 (In Ukrainian).
  9. American Diabetes Association Professional Practice Committee (2022) 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes. 2022 – Diabetes Care. 2022; 45(1): 17–38. Available from: https://doi.org/10.2337/ dc22-S002.
  10. Kaiser AB, Zhang N, Van Der Pluijm W. Global prevalence of type 2 diabetes over the next ten years (2018–2028). Diabetes. 2018; 67(1): 202. Available from: https://doi.org/10.2337/db18-202-LB.
  11. Hongjiang Wuю, Christopher C Patterson., Xinge Zhang. et al. Worldwide estimates of incidence of type 2 diabetes in children and adolescents in 2021. Diabetes Research and Clinical Practice. 2022; 185: 109785. Available from: https://doi. org/10.1016/j.diabres.2022.109785.
  12. Zelinska NB, Hryshchenko KV, Hloba YeV. Type 2 diabetes mellitus in children and adolescents in the world and in Ukraine. Ukrainian Journal of Pediatric Endocrinology. 2021; 1(37): 4–16 (In Ukrainian). Available from: https://doi.org/10.30978/ UJPE2021-1-4.
  13. Tuliantseva YeO, Velychko BI. Assessment of the quality of life of patients with type 2 diabetes. International scientific conference. 2022 July 29–30; Riga, the Republic of Latvia: 188–192 (In Ukrainian). Available from: https://repo.odmu.edu.ua:443/xmlui/handle/123456789/11624.
  14. Tronko MD, Bolshova OV, Sokolova LK, Belchina YuB. Type 2 diabetes mellitus: etiology, pathogenesis, clinic, diagnosis and treatment. Endoсrynologia. 2021; 10 (4): 35–44 (In Ukrainian).
  15. Centers for Disease Control and Prevention. National Diabetes Statistics Report, 2020: Estimates of Diabetes and Its Burden in the United States. Accessed 15 October 2020. Available from: https://www.cdc.gov/diabetes/pdfs/data/statistics/national- diabetes-statistics-report.pdf.
  16. Chung WK, Erion K, Florez JC et al. Precision Medicine in Diabetes: A Consensus Report From the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2020; 43(7): 1617–1635 doi: 10.2337/dci20-0022.
  17. Musiienko VA, Marushchak MI. Genetic markers of type 2 diabetes. Medical and Clinical Chemistry. 2019; 21(4): 184-19 (In Ukrainian). DOI: https://doi.org/10.11603/mcch.2410-681X.2019.v.i4.10688.
  18. American Diabetes Association Professional Practice Committee (2022). 10. Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes–2022. Diabetes Care. 2022; 45(1): 144–174. Available from: https://doi.org/10.2337/ dc22-S010.
  19. American Diabetes Association Professional Practice Committee (2022). 12. Retinopathy, Neuropathy, and Foot Care: Standards of Medical Care in Diabetes–2022. Diabetes Care. 2022; 45(1): 185–194. Available from: https://doi.org/10.2337/ dc22-S012.
  20. Panina SS, Hondulenko NO, Sanina NA et al. Prevention and ways to reduce disability due to diabetes. Ukrainian Bulletin of Medical and Social Expertise. 2018; 3-4(29-30): 23–29 (In Ukrainian). Available from: http://nbuv.gov.ua/UJRN/ ujmse_2018_3-4_7.
  21. Cosentino F, Grant PJ, Aboyans V et al. 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. European Heart Journal. 2020; 41(2): 255–323. doi: 10.1093/eurheartj/ehz486.
  22. Knuuti J, Wijns W, Saraste A et al. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. European Heart Journal. 2020; 41(3): 407-477 doi: 10.1093/eurheartj/ehz425.
  23. Ibanez B, James S, Agewall S et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: the Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). European Heart Journal. 2018; 39(2): 119-177 doi: 10.1093/eurheartj/ehx393.
  24. American Diabetes Association (2021). 11. Microvascular Complications and Foot Care: Standards of Medical Care in Diabetes-2021. Diabetes Care. 2021; 44(1): 151–167 doi: 10.2337/dc21-Srev.
  25. Fisher VL, Tahrani AA. Cardiac autonomic neuropathy in patients with diabetes mellitus: current perspectives. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2017; 10: 419–434. Available from: https://doi.org/10.2147/DMSO. S129797
  26. Briukhova OV, Mankovsky BM. Structural changes of myocardium in patients with diabetes mellitus 2 type and cardiac autonomic neuropathy. Problems of Endocrine Pathology. 2018; 1:16-21 (In Ukrainian). Available from: https://doi. org/10.21856/j-PEP.2018.1.02.
  27. Serhiienko VO, Serhiienko OO. Diabetes mellitus and acute coronary syndromes. International Journal of Endocrinology. 2021; 7(4): 346-360 (In Ukrainian). Available from: https://doi.org/10.22141/2224-0721.17.4.2021.237351.
  28. American Diabetes Association Professional Practice Committee (2022). 11. Chronic Kidney Disease and Risk Management: Standards of Medical Care in Diabetes–2022. Diabetes Care. 2022; 45(1): 175–184 Available from: https://doi.org/10.2337/ dc22-S011.
  29. Ieromenko HV, Ospanova TS, Bezditko TV, Blazhko VI. Asthma and diabetes mellitus 2 type – polymorbidity of the XXI century. Asthma and Allergy. 2019; 1: 27-30 (In Ukrainian) DOI: 10.31655/2307-3373-2019-1-27-30.
  30. Sirchak YeS, Patskun SV. The frequency of Helicobacter pylori in patients with combination of the diabetes mellitus 2 type and chronic gastritis. Achievements of Clinical and Experimental Medicine. 2017; 2: 70–75 (In Ukrainian) doi 10.11603/1811-2471.2017.v0.i2.7653.
  31. Buzduhan IO, Fediv OI. Quality of life in patients with peptic ulcer ofthe stomach and duodenum in combination with hypertension and type 2 diabetes mellitus in the presence oftoxigenic (cagA+, vacA+) strains of Helicobacter pylori. Ukrainian Medical Journal. 2020; 2/6(140): 1-3 (In Ukrainian) DOI: 10.32471/umj.1680-3051.140.196155.
  32. Dynia YuZ. Clinical and pathogenetic features of intestinal lesions in patients with type 2 diabetes mellitus. Modern Gastroenterology. 2021; 5-6 (121-122): 30–36 (In Ukrainian). Available from: http://doi.org/10.30978/MG-2021-5-30.
  33. Dorofieiev AE, Shvets NI, Parkhomenko TA, Dynia YuZ, Chychula YuV. Diabetic enterocolopathy in patients with type 2 diabetes. International Journal of Endocrinology. 2019; 15(1): 61-65 (In Ukrainian).
  34. Aw W., Fukuda S. Understanding the role of the gut ecosystem in diabetes mellitus. Journal of Diabetes Investigation. 2018; 9:5–12. Available from: https://doi.org/10.1111/jdi.12673.
  35. Gerard C, Vidal H. Impact of Gut Microbiota on Host Glycemic Control. Endocrinol (Lausanne). 2019; 30:1–13. Available from: https://doi.org/10.3389/fendo.2019.00029.
  36. Gurung M, Li Zh, You H. et al. Role of gut microbiota in type 2 diabetes pathophysiology. 2020; 51:102590. Available from: https://doi.org/10.1016/j.ebiom.2019.11.051.
  37. Sirchak YeS, Sidei SM, Vais VV. Large intestine dysbiosis in patients with combination of diabetes mellitus type 2 and chronic noncalculous cholecystitis. Achievements of Clinical and Experimental Medicine. 2018; 2: 112-115 (In Ukrainian). DOI 10.11603/1811-2471.2018.v0.i2.8483.
  38. Klenovska SV, Shnaider SA, Maslov OV. Peculiarities of oral cavity microbiota changes in diabetes mellitus patients. Bulletin of Dentistry. 2019; 32(2): 29-33 (In Ukrainian) DOI 10.35220/2078-8916-2019-32-2-29-33.
  39. Setji T, Hopkins ThJ, Jimenez M. Rationalization, Development, and Implementation of a Preoperative Diabetes Optimization Program Designed to Improve Perioperative Outcomes and Reduce Cost. Diabetes Spectr. 2017; 30(3): 217–223. Available from: https://doi.org/10.2337/ds16-0066.
  40. Do DV, Han G, Abariga SA, Sleilati G, Vedula SS, Hawkins BS. Blood pressure control for diabetic retinopathy. Cochrane Database of Systematic Reviews. 2023; 3(3): 006127. Available from: https://doi.org/10.1002/14651858.CD006127.pub3
  41. Tarr JM, Kaul K, Chopra M, Kohner EM, Chibber R. Pathophysiology of Diabetic Retinopathy. ISRN Ophthalmology. 2013; 2013: 343560. DOI: 10.1155/2013/343560.
  42. Zherdova NM, Medvedovska NV, Makeiev SS, Mankovskyi BM. The relationship between diabetic retinopathy and cerebrovascular disease perfusion in patients with type II diabetes. Journal of Ophthalmology. 2018; 1(480): 49-53 (In Ukrainian).
  43. Garcia-Serrano AM, Duarte J. Brain Metabolism Alterations in Type 2 Diabetes: What Did We Learn From Diet-Induced Diabetes Models? Frontiers in neuroscience. 2020; 14: 229. Available from: https://doi. org/10.3389/fnins.2020.00229.
  44. Tumanskyi VO, Avramenko YuM. Pathomorphological changes of capillaries in the cerebral cortex in type 2 diabetes mellitus. Current issues in pharmacy and medicine: science and practice. 2021; 14(3): 354-362 (In Ukrainian) DOI:10.147 39/2409-2932.2021.3.244360.
  45. Pashkovska NV. Cognitive impairment in patients with type 2 diabetes mellitus: the role of hypoglycemic therapy. International journal of endocrinology. 2018; 14(1): 76-85 (In Ukrainian) DOI: 10.22141/2224-0721.14.1.2018.127097.
  46. Biessels GJ, Strachan MWJ, Visseren FLJ, Kappelle LJ, Whitmer RA. Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions. Lancet Diabetes Endocrinol. 2014; 2(3): 246–55 DOI: 10.1016/ S2213-8587(13)70088-3.
  47. Kondratenko AP. Cognitive and emotional disturbances of patients with type 2 diabetes mellitus. Experimental and Clinical Medicine. 2022; 4(89): 49-52 (In Ukrainian). Available from: https://doi.org/10.35339/ekm.2020.89.04.07.
  48. Shuprovych AA, Zinych OV. Nervous-mental stress and cognitive disorders as components of stress state in type 2 diabetic patients. Revie. Clinical endocrinology and endocrine surgery. 2022; 2(78): 61-68 (In Ukrainian). Available from: http://doi. org/10.30978/CEES-2022-2-61.
  49. Elsharkawy RE, Abdel Azim GS, Osman MA et al. Peripheral polyneuropathy and cognitive impairment in type II diabetes mellitus. Neuropsychiatr Disease and Treatment. 2021; 17: 627-635 doi: 10.2147/NDT.S284308.
  50. Duong V, Iwamoto A, Pennycuff J, Kudish B, Iglesia C. A systematic review of neurocognitive dysfunction with overactive bladder medications. Int Urogynecol J. 2021; 32(10): 2693-2702 doi: 10.1007/s00192-021-04909-5.
  51. Zherdova NM. Cognitive disorders in elderly patients with type 2 diabetes. The Health of Society. 2017; 6(1/2): 49–52 (In Ukrainian). Available from: http://nbuv.gov.ua/UJRN/zdc_2017_6_1-2_12.
  52. Munshi MN. Cognitive Dysfunction in older adults with diabetes: what a clinician needs to know. Diabetes Care. 2017; 40(4): 461-467 doi: 10.2337/ dc16-1229.
  53. Papathanasiou A, Koutsovasilius A, Shea S et al. The Problem Areas in Diabetes (PAID) scale: psychometric evaluation survey in a Greek sample with type 2 diabetes. J Psychiatr Ment Health Nurs. 2014; 21(4): 345-53 doi: 10.1111/j.1365-285 0.2012.01875.x.
  54. Shevchuk MV, Tsyhanenko OO, Taranenko OV, Kryzhevskyi VV, Mankovskyi BM. The practical importance of depression diagnosis in type 2 diabetes mellitus patients. International journal of endocrinology. 2019; 15(1): 50-54 (In Ukrainian). doi: 10.22141/2224-0721.15.1.2019.158695.
  55. Velychko VI, Nikitina VI, Said EV, Amirova AYu. The psychological and emotional state of patients with type 2 diabetes mellitus on the background of excessive body weight. Journal of Education, Health and Sport. 2017; 7(3): 531-539. Available from: http://dx.doi.org/10.5281/zenodo.495479.
  56. Ameres M, Brandstetter S, Toncheva AA et al. Association of neuronal injury blood marker neurofilament light chain with mild-to-moderate COVID-19. Journal of Neurology. 2020; 267(12): 3476–3478 doi: 10.1007/s00415-020-10050-y
  57. Kanberg N, Ashton NJ, Andersson LM et al. Neurochemical evidence of astrocytic and neuronal injury commonly found in COVID-19. 2020; 95(12): 1754-1759 doi: 10.1212/WNL.0000000000010111.
  58. Taquet M, Luciano S, Geddes JR, Harrison PJ. Bidirectional associations between COVID-19 and psychiatric disorder: retrospective cohort studies of 62,354 COVID-19 cases in the USA. Lancet Psychiatry. 2021; 8(2): 130-140 DOI: 10.1016/ S2215-0366(20)30462-4.
  59. Guo W, Li M, Dong Ya et al. Diabetes is a risk factor for the progression and prognosis of COVID-19. Diabetes Metabolism Research and Reviews. 2020; 36(7): 3319. Available from: https://doi.org/10.1002/dmrr.3319.
  60. Guan W-jie, D Ph, Ni Zh-yi et al. Clinical characteristics of coronavirus disease 2019 in China. New England Journal of Medicine. 2020; 382: 1708-1720 doi:10.1056/NEJMoa2002032.
  61. Li B, Yang J, Zhao F et al. Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China. Clinical Research in Cardiology. 2020; 109: 531-538 doi:10.1007/s00392-020-01626-9.
  62. Yan Y, Yang Y, Wang F et al. Clinical characteristics and outcomes of patients with severe COVID-19 with diabetes. BMJ Open Diabetes Res Care. 2020; 8(1): 001343 doi: 10.1136/bmjdrc-2020-001343.
  63. Shenoy A, Ismaily M, Bajaj M. Diabetes and Covid-19: a global health challenge. BMJ Open Diabetes Res Care. 2020; 8(1): 001450 doi:10.1136/ bmjdrc-2020-001450.
  64. Zhao Zh, Wang Sh, Ma W et al. Diabetes mellitus increases the incidence of deep vein thrombosis after total knee arthroplasty. Archives of Orthopaedic and Trauma Surgery. 2014; 134(1): 79-83 doi: 10.1007/s00402-013-1894-3.
  65. Urbanovych AM, Dunets YuV. Peculiarities of the course of anemic syndrome in patients with diabetes mellitus. 2021; 26(1): 75-81 (In Ukrainian). DOI: 10.31793/1680-1466.2021.26-1.75.
  66. Yang W, Cai X, Wu H, Ji L. Associations between metformin use and vitamin B12 levels, anemia, and neuropathy in patients with diabetes: a meta-analysis. Journal of Diabetes. 2019; 11(9): 729-743 doi: 10.1111/1753-0407.12900.
  67. Bell DSH. Metformin-induced vitamin B12 deficiency can cause or worsen distal symmetrical, autonomic and cardiac neuropathy in the patient with diabetes. Diabetes Obes Metab. 2022; 24(8): 1423-1428 doi: 10.1111/dom.14734.
  68. Tykhonova TM, Smilka YuM. Diabetic polyneuropathies: options of the course and influence on the quality of patients’ life. Problems of Endocrine Pathology. 2019; 69(3): 144-148 (In Ukrainian). Available from: https://doi.org/10.21856/j-PEP.2019.3.19.
  69. Pop-Busui R, Boulton AJM, Feldman EL et al. Diabetic Neuropathy: A Position Statement by the American Diabetes Association. Diabetes Care. 2017; 40(1): 136–154. Available from: https://doi.org/10.2337/dc16-2042.
  70. Cignarelli А, Genchi VA, Caruso I et al. Diabetes and cancer: pathophysiological fundamentals of a ‘dangerous affair’ Diabetes Res Clin Pract. 2018; 143: 378–388 DOI: 10.1016/j.diabres.2018.04.002.
  71. Zhuravlova LV, Sokolnikova NV. The diabetes mellitus and oncopathоlogy. Medicines of Ukraine. 2021; 2 (248): 32-40 (In Ukrainian). Available from: https://doi.org/10.37987/1997-9894.2021.2(248).229022.
  72. Velychko VI, Mykhailenko VL, Lahoda DO, Volokhova HO, Lyashenko SL. Screening for diabetes and prediabetes: new communication opportunities. Reproductive endocrinology. 2021; 5(61): 92-95 (In Ukrainian). Available from: http://dx.doi. org/10.18370/2309-4117.2021.62.92-95.
  73. Velychko VI, Said OV, Kolotvina LI, Karpynska TL, Astvatsatrian HR. Results of screening for disorders of carbohydrate metabolism and type 2 diabetes among Odesa residents. Family medicine. 2015; 5: 132-134 (In Ukrainian).
  74. Chadha Ch, Pittas AG, Lary ChW et al. Reproducibility of a prediabetes classification in a contemporary population. Metabol Open. 2020; 6: 100031 DOI: 10.1016/j.metop.2020.100031.
  75. American Diabetes Association Professional Practice Committee (2021) 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes. 2021 – Diabetes Care. 2021; 44(1): 15-33 DOI: 10.2337/dc21-S002.