Abstract:
The purpose of the investigation was to estimate the effectiveness of peroxisomal proliferator-activated γ-receptors (PPARγ) modulation upon the antiseizure effects of transcranial direct current stimulation (tDCS). In rats with the kindling syndrome was induced
by i.p. injections of pentylenetetrazol (PTZ; 30.0 mg/kg daily, for three weeks). For tDCS active electrode was located over cerebellar
zone of cranium (10 mm2). The latent period of seizures induced by a test injection of PTZ (30 mg/kg) increased significantly (by 22.5% on average P b .05 vs. control) after tDCS (600 μA, 10.0 min, cathode on the skull surface).
