Abstract:
The study involved clinical and laboratory examination of 54 women with vasomotor
menopausal disorders divided into 3 subgroups depending on the duration of symptoms
(not more than 12 months, about 3 years, from 5 to 7 years). The control group included
21 patients without vasomotor disorders during the menopausal period. Data from the
general and obstetric-gynecological anamnesis and the results of objective and general
clinical examinations were analyzed. To assess the state of intestinal microbiocenosis
in patients, a bacteriological study of feces was used according to modern methods.
In women with menopausal vasomotor disorders, chronic arterial hypertension, overweight, diabetes mellitus, chronic enterocolitis, and chronic pyelonephritis prevailed
among somatic diseases. The study also revealed that these patients had a pronounced
imbalance of the intensive microbiota, which was characterized by a significant decrease
in the main representatives of the obligate microflora (Bifidobacterium, Lactobacillus)
and an increase in the number of opportunistic strains (Klebsiella and Clostridiodes
difficile). Considering modern concepts, a change in the microbial composition of the
intestine may be one of the possible trigger factors for the occurrence of vasomotor
menopausal disorders. Further research will clarify the influence of the microbiome on
the formation of the pathological menopausal symptom complex and improve the preventive and therapeutic measures in this category of women.
