N 2 (199) 2026. P. 49–55

ROLE OF THE SINGLE-NUCLEOTIDE VARIANT rs17492553 OF THE UMAMI RECEPTOR GENE TAS1R1 IN THE DEVELOPMENT OF METABOLICALLY UNHEALTHY OBESITY IN CHILDREN

O. E. Abaturov, A. O. Nikulina, D. L. Shulzhenko

Dnipro State Medical University, Dnipro, Ukraine
Municipal Non-Profit Enterprise “City Clinical Hospital No. 6” of the Dnipro City Council”, Dnipro, Ukraine

DOI 10.32782/2226-2008-2026-2-7

Background. Altered umami taste perception associated with the single nucleotide variant (SNV) in the taste 1 receptor member 1 (TAS1R1) gene may contribute to excess fat accumulation and predict the obesity phenotype.

Objective: To determine the risk of developing metabolically unhealthy obesity in children with SNV rs17492553 TAS1R1.

Methods. 350 children with obesity aged 6–18 years were examined. Among obese children, two observation subgroups with metabolically unhealthy obesity (MUO, n = 204) and metabolically healthy obesity (MHO, n = 146), were separated. The level of basal glycemia, insulinemia was studied by immunochemical method with electrochemiluminescent detection, high-density lipoproteins and triglycerides – by enzymatic-colorimetric method in the Synevo (Ukraine). SNVs of the TAS1R1 gene were identified by whole-genome next-generation sequencing in 52 children at the CeGaT laboratory (Germany).

Results. Of the six identified SNVs (rs10864628, rs17492553, rs34160967, rs35118458, rs35375392, rs41278020) of TAS1R1, only SNV rs17492553 was associated with the development of MUO, determining an increase in gonadotropins and a decrease in 25-hydroxycalciferol in serum.

Conclusions. Carriers of the CT genotype of SNV rs17492553 TAS1R1 are 2.73 times more likely to develop metabolically unhealthy obesity than CC homozygotes.

Keywords: children, obesity, single nucleotide variants, taste 1 receptor member 1.

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