Odesa National Medical University, Odesa, Ukraine
DOI 10.32782/2226-2008-2025-6-7
Introduction. Intraoperative injury to the recurrent laryngeal nerve (RLN) remains a significant complication of thyroid surgery, potentially leading to voice disorders and reduced quality of life. Visual identification of the RLN is considered the gold standard, though its limitations in complex cases have prompted the use of intraoperative neuromonitoring (IONM). Despite international endorsement, IONM remains underutilized in Ukraine.
Objective – to evaluate the initial experience and clinical feasibility of IONM during thyroid surgeries at Odesa National Medical University, and its potential benefits for surgical outcomes and nerve preservation.
Materials and Methods. A prospective randomized cohort study was conducted from 2020 to 2023, including 74 patients undergoing thyroidectomy. Nineteen patients were operated on using IONM (main group), and 55 without it (control group). The ASA classification was used to assess perioperative risk. Voice-related quality of life was measured using the V-RQOL questionnaire at baseline and up to 12 months postoperatively. Nerve identification, postoperative vocal cord paresis, and quality-of-life scores were statistically analyzed.
Results. Bilateral RLN identification was achieved in 89.5% of the IONM group versus 47.3% in the control group. Vocal cord paresis occurred in 10.5% of IONM cases and 29.1% without IONM, though the difference was not statistically significant (p=0.10). Most cases were transient. By 12 months, quality-of-life scores showed no significant difference between groups. However, IONM proved most useful in reoperations and inflammatory thyroid disease.
Conclusions. IONM improves RLN visualization and functional assessment during thyroid surgery, reducing nerve injury risk and enhancing surgical safety, particularly in high-risk cases. These findings support broader implementation of IONM in Ukrainian surgical practice.
Key words: neuromonitoring, thyroid surgery, quality of life, surgical results, endocrine surgery.
REFERENCES
- Papagoras D, Tzikos G, Douridas G, et al. Visualization of the recurrent laryngeal nerve alone versus intraoperative nerve monitoring in primary thyroidectomy: a framework approach to a missing typology. Front Surg. 2023;24;10:1176511. https://doi.org/10.3389/fsurg.2023.1176511.
- Grishaeva P, Kussmann J, Burgstaller T, Klutmann S, Linder K, Fendrich V. Recurrent laryngeal nerve paresis in benign thyroid surgery with and without intraoperative nerve monitoring. Minerva Surg. 2022;77(6):558–563. https://doi.org/ 10.23736/S2724-5691.22.09421-7.
- Potenza AS, Araujo Filho VJF, Cernea CR. Injury of the external branch of the superior laryngeal nerve in thyroid surgery. Gland Surg. 2017;6(5):552–562. https://doi.org/10.21037/gs.2017.06.15.
- Choi SY, Son YI. Intraoperative neuromonitoring for thyroid surgery: the proven benefits and limitations. Clin Exp Otorhinolaryngol. 2019;12(4):335–336. https://doi.org/10.21053/ceo.2019.00542.
- Deshmukh A, Thomas AE, Dhar H, et al. Seeing is not believing: intraoperative nerve monitoring (IONM) in the thyroid surgery. Indian J Surg Oncol. 2022;13(1):121–132. https://doi.org/10.1007/s13193-021-01348-y.
- Schneider R, Machens A, Lorenz K, Dralle H. Intraoperative nerve monitoring in thyroid surgery – shifting current paradigms. Gland Surg. 2020;9(Suppl 2):S120–S128. https://doi.org/10.21037/gs.2019.11.04.
- Saxe A, Idris M, Gemechu J. Does the use of intraoperative neuromonitoring during thyroid and parathyroid surgery reduce the incidence of recurrent laryngeal nerve injuries? A systematic review and meta-analysis. Diagnostics (Basel). 2024;14(9):860. https://doi.org/10.3390/diagnostics14090860.
- Rossini M, Cozzani F, Loderer T, Bonati E, Giuffrida M, Del Rio P. Intraoperative neuromonitoring, nerves at risk and staged thyroidectomy: our experience on 377 consecutive cases. Acta Biomed. 2022;93(2):e2022040. https://doi.org/10.23750/ abm.v93i2.11178.
- Cirocchi R, Arezzo A, D’Andrea V, et al. Intraoperative neuromonitoring versus visual nerve identification for prevention of recurrent laryngeal nerve injury in adults undergoing thyroid surgery. Cochrane Database Syst Rev. 2019;1(1):CD012483. https://doi.org/10.1002/14651858.CD012483.pub2.
- Cherenko S. Review of the 2023 World Congress on Thyroid Cancer (WCTC 2023, London): is there light at the end of the tunnel for patients with neglected cancer? Int J Endocrinol. 2024;19(8):609–616. (In Ukrainian). https://doi.org/10.22141/ 2224-0721.19.8.2023.1335.
- Shidlovskyi OV, Shidlovskyi VO, Sheremet MI, Duts SI. Prevention of intraoperative laryngeal nerve injuries: literature review and own data. Clinical endocrinology and endocrine surgery. 2022;3(79):68–77. (In Ukrainian). https://doi.org/ 10.30978/CEES-2022-3-68.
- Shidlovskyi VO, Shidlovskyi OV, Dyvak AM, Pryvrotskyi VM. Intraoperative neuromonitoring in prevention of laryngeal nerve injuries. Achievements of clinical and experimental medicine. 2022;2:173–177. (In Ukrainian). https://doi.org/10.11603/ 1811-2471.2022.v.i2.13148/.
- Allen E, Fingeret A. Anatomy, Head and Neck, Thyroid. [Updated 2025 Jun 23]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan. Available from: https://www.ncbi.nlm.nih.gov/books/NBK470452/ .
- Horvath B, Kloesel B, Todd MM, et al. The evolution, current value, and future of the American Society of Anesthesiologists Physical Status Classification System. 2021;135(5):904–919. https://doi.org/10.1097/ ALN.0000000000003947.
- Wolfberg J, Whyte J, Doyle P, at el. Rehabilitation Treatment Specification System for Voice Therapy: application to everyday clinical care. Am J Speech Lang Pathol. 2024;33(2):814–830. https://doi.org/10.1044/2023_AJSLP-23-00283.
- TIBCO Software Inc. Guide to statistics. Available from: https://docs.tibco.com/pub/spotfire_s_plus/8.2.0_november_2010/ pdf/TIB_sf_s+_8.2.0_stats2_guide.pdf?id=12.
