Odesa National Medical University, Odesa, Ukraine
Introduction. The study of the external respiratory function (spirometry) is a generally recognized gold standard for the study of the respiratory system, mandatory for many pulmonary diseases. Global standards for the management of patients with bronchial asthma (GINA) and chronic obstructive lung disease define spirometry as the main method for assessing the effectiveness of treatment and determining the prognosis of these diseases. At the same time, the stress nature of the study and the tests performed during the study with inhaled adrenomimetics as bronchodilators can have a significant effect on the cardiovascular system of the patients being examined. Adrenomimetics are expected to cause an increase in heart rate and tachycardia-related arrhythmias – atrial fibrillation and similar conditions.
Objective: present a case of the “atypical” side effect of bronchodilator test during spirometry.
Results. The article presents a case of bigeminy, which developed as a side effect of a test with bronchodilators (salbutamol) during the study of the external respiratory function. This response to adrenergic drugs may be considered as atypical, since there is general agreement that tachycardia should prevent the development of ventricular bigeminy. The study was conducted on a patient with pneumofibrosis (pneumoconiosis), which developed as a result of long-term work in conditions of increased dustiness.
Conclusions. Cardiovascular pathology associated with pneumoconiosis may be considered a possible explanation for the development of bigeminy following salbutamol administration.
Keywords: functional diagnostics, spirometry, bronchodilator test, arrhythmia.
REFERENCES
- Graham BL, Steenbruggen I, Miller MR, et al. Standardization of Spirometry 2019 Update. An Official American Thoracic Society and European Respiratory Society Technical Statement. American Journal of Respiratory and Critical Care Medicinе. 2019 Oct 15; 200(8): e70–e88. https://doi.org/10.1164/rccm.201908-1590ST.
- Hankinson JL, Eschenbacher B, Townsend M, Stocks J, Quanjer PH. Use of forced vital capacity and forced expiratory volume in 1 second quality criteria for determining a valid test. European Respiratory Journal. 2015; 45(5): 1283–1292. https://doi.org/10.1183/09031936.00116814.
- Kaminsky DA, Cockcroft DW, Davis BE. Respiratory System Dynamics. Seminars in Respiratory and Critical Care Medicine. 2023 Jul 10; 44(05): 526–537. 10.1055/s-0043-1770058.
- Roberts C, Ward S, Walsted ES, Hull JH. Safety of pulmonary function testing: data from 20 years. Thorax. 2018 Apr; 73(4): 385–7. https://doi.org/10.1136/thoraxjnl-2017-210246.
- Global Initiative for Asthma (GINA). Global Strategy for Asthma Management and Prevention: 2024 Update [Internet]. Fontana, WI: Global Initiative for Asthma; 2024 [cited 2025 Oct 29]. Available from: https://ginasthma.org/wp-content/ uploads/2024/05/GINA-2024-Strategy-Report-24_05_22_WMS.pdf.
- Emeryk A, Janeczek K, Markut-Miotła E, Pirożyński M, Florkiewicz E. Bronchodilator response after two methods of salbutamol nebulization in asthmatic children. Advances in Dermatology and Allergology. Postępy Dermatologii i Alergologii. 2022 Dec; 39(6): 1027–1034. https://doi.org/10.5114/ada.2022.117038.
- Gogayeva, OK, Lebid AY, Tymoshenko DA. Comorbidities in Patients before Surgical Myocardial Revascularization: Current State of the Problem. Part IІ [Komorbidnist u patsiyentiv pered khirurhichnoyu revaskularyzatsiyeyu miokarda: suchasnyy stan problemy. Chastyna IІ]. Ukrainian Journal of Cardiovascular Surgery. 2022 Sep 26; 30(3): 22–28. https:// doi.org/10.30702/ujcvs/22.30(03)/GL039-2228 (In Ukranian).
- Potashev SV, Salo SV, Gavrylyshyn AY, Hrubyak LM, Unitska OM, Fedkiv SV. Longitudinal Strain by Speckle Tracking during Dobutamine Stress Echocardiography in Suspected Coronary Arteries Disease [Longitudinalna deformatsiya miokarda za metodom speckle tracking pid chas dobutamin-stres-ekhokardiohrafiyi u khvorykh iz pidozroyu na ishemichnu khvorobu sertsya]. Ukrainian Journal of Cardiovascular Surgery. 2020 Dec 16; (4(41): 15–25. https://doi.org/10.30702/ ujcvs/20.4112/032015-025/73.7 (In Ukranian).
- Norouzi J, Papadakis M, Akbarnejad A, Anvari M. The role of pre-participation cardiac evaluation in the management of an athlete with premature ventricular contraction-induced cardiomyopathy: a case report. Eur Heart J Case Rep. 2022 May 16; 6(5): ytac174. https://doi.org/10.1093/ehjcr/ytac174.
- Sethi R, Zakharyan H, Muradyan A. Salbutamol and ipratropium bromide are high risk factors for atrial arrhythmias in patients with COPD and CVS diseases. European Respiratory Journal. 2019; 54(suppl 63): PA2462. https://doi.org/ 10.1183/13993003.congress-2019.PA2462.
- Zeppenfeld K, Tfelt-Hansen J, de Riva M, et al. 2022 ESC Guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: Developed by the Task Force for the Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death of the European Society of Cardiology (ESC). Eur Heart J. 2022 Oct 21; 43(40): 3997–4126. https://doi.org/10.1093/eurheartj/ehac262.
