N 5 (196) 2025. P. 61–65

GASTROESOPHAGEAL REFLUX DISEASE AND CARDIОVASCULAR DISEASES: INTERRELATION AND MUTUAL INFLUENCE (LITERATURE REVIEW)

L. I. Kolotvina, G. V. Kornovan, V. I. Synenko, A. O. Kolotvin

Odesa National Medical University, Odesa, Ukraine

DOI 10.32782/2226-2008-2025-5-10

Introduction. The work is dedicated to the problem of comorbidity with cardiovascular disease and gastroesophageal reflux disease.

Objective. Analyze the information in current literary and electronic resources regarding the clinical features of the current history of heart failure and illness of the cardiovascular system.

Materials and methods. An analysis of scientific information was carried out from the following databases: Scopus, Web of Science, MedLine, PubMed, Google Scholar, Global Health, ResearchGate, as well as WHO, Ministry of Health of Ukraine and other Internet resources. Results. The work presents a review of the current scientific literature on the problem of interconnection and interrelation of the cardiovascular system and illness of the cardiovascular system. Some of the manifestations associated with reflux disease include transient disturbances in heart rhythm and conduction, usually supraventricular extrasystole and atrial fibrillation. Experts note that gastroesophageal reflux is a major trigger for arrhythmia. The problem of the connection between gastroesophageal reflux disease and ischemic heart disease is even relevant, which will require, in case of pain syndrome in the chest, to carry out detailed treatment of the patient to identify the pain, both on the side of the heart and on the side to the walker. It is also necessary to ensure the presence of causal links in the presence of

gastroesophageal reflux disease and arterial hypertension.

Conclusion. Obvious comorbidity is associated with significant diagnostic difficulties and will require individual comprehensive treatment of such patients. The data expands the knowledge of the more common clinical features of esophagocardial interaction and is the basis for optimizing medical tactics for this category of patients.

Keywords: gastroesophageal reflux disease, atrial fibrillation, ischemic heart disease, arterial hypertension.

REFERENCES

  1. Chamberlain AM, Alonso A, Noseworthy PA, et al. Multimorbidity in patients with atrial fibrillation and community controls: A population-based study. J Multimorb Comorb. 2024 Dec 21; 14: 26335565241310281. DOI: 10.1177/26335565241310281.
  2. Tan MMC, Barbosa MG, Pinho PJMR, et al. Determinants of multimorbidity in low- and middle-income countries: A systematic review of longitudinal studies and discovery of evidence gaps. Obes Rev. 2023 Feb; 25(2): e13661. DOI: 10.1111/ obr.13661.
  3. Abrahamovych O, Fayura O, Abrahamovych U. Komorbidnist: suchasnyy pohlyad na problemu; klasyfikatsiya (pershe povidomlennya). [Comorbidity: a Modern View on the Problem; Classification (first notice)]. Lviv clinical bulletin. 2015; 4(12): 56–64. https://doi.org/10.25040/lkv2015.04.056. (In Ukrainian).
  4. Marabotto E, Pasta A, Calabrese F, et al. The Clinical Spectrum of Gastroesophageal Reflux Disease: Facts and Fictions. Visc Med. 2024 Oct; 40(5): 242–249. DOI: 10.1159/000536583.5.
  5. Kashyrtseva OM, NovokhatniaA Ye, Khomenko LO, Oparin AA, Oparina TM. EndotheliaL dysfunction and gastroesophageal reflux disease: study of common pathogenetic mechanisms and ways of correction. Clinical and preventive medecine. 2024; 2: 75–82. https://doi.org/10.31612/2616-4868.2.2024.10. (In Ukrainian).
  6. Prikhodko VYu, Moreva DYu. Peculiarities of gastroesophageal reflux disease in elderly people. Problemy starinnia ta dovholittia. 2015; 24(1): 58–77. http://old.geront.kiev.ua/library/psid/t24/n1/Prikhodko. (In Ukrainian).
  7. Fadieienko GD, Nesen AO, Krakhmalova OO, Izmailova OV. Mechanisms of formation of comorbidity of gastroesophageal reflux disease and coronary heart disease. Modern Gastroenterоlogy. 2018; 3(101): 7–13. https://doi.org/10.30978/ MG-2018-3-7. (In Ukrainian).
  8. Gesualdo M, Scicchitano P, Carbonara S, et al. The association between cardiac and gastrointestinal disorders: causal or casual link? J Cardiovasc Med (Hagerstown). 2016 May; 17(5): 330–8. DOI: 10.2459/JCM.0000000000000351.
  9. Liang J, Tang L, Yang J, Li Y, Yang X, Hou C. Gastroesophageal reflux disease and risk for arrhythmias: a Mendelian randomization analysis. Front Cardiovasc Med. 2024 Jul 29; 11: 1411784. DOI: 10.3389/fcvm.2024.1411784.
  10. Stepanov YuM, Mosiychuk LM, Tatarchuk OM, Shevtsova OM, Petishko OP. Vplyv vistseralnoho ozhyrinnya na tsytokinovu ta hormonalnu rehulyatsiyu u patsiyentiv iz hastroezofahealnoyu reflyuksnoyu khvoroboyu [Effects of visceral obesity on cytokine and hormonal regulation in patients with gastroesophageal reflux disease]. Gastroenterologìa. 2023; 3(57): 19–24. https://doi.org/10.22141/2308-2097.57.3.2023.551. (In Ukrainian).
  11. Lei WY, Wang JH, Wen SH, et al. Risk of acute myocardial infarction in patients with gastroesophageal reflux disease: A nationwide population-based study. PLoS One. 2017 Mar 20; 12(3): e0173899. DOI: 10.1371/journal.pone.0173899.
  12. Eusebi LH, Ratnakumaran R, Yuan Y, Solaymani-Dodaran M, Bazzoli F, Ford AC. Global prevalence of, and risk factors for gastro-oesophageal reflux symptoms: a meta-analysis. Gut. 2018; 67(3): 430–440. DOI: 10.1136/gutjnl-2016–313589.
  13. Saklayen MG. The Global Epidemic of the Metabolic Syndrome. Curr Hypertens Rep. 2018 Feb 26; 20(2): 12. DOI: 10.1007/s11906-018-0812-z.
  14. Zhuravlyova LV, Filonenko MV. Gastroesophageal reflux disease in patients with metabolic syndrome: the peculiarities of clinical course and the modern approaches to treatment. Modern Gastroenterоlogy. 2018; 4: 90–95. https://doi.org/10.30978/ MG-2018-3-90. (In Ukrainian).
  15. Loke SS, Yang KD, Chen KD, Chen JF. Erosive esophagitis associated with metabolic syndrome, impaired liver function, and dyslipidemia. World J Gastroenterol. 2013 Sep 21; 19(35): 5883–8. DOI: 10.3748/wjg.v19.i35.5883.
  16. Bou Daher H, Sharara AI. Gastroesophageal reflux disease, obesity and laparoscopic sleeve gastrectomy: The burning questions. World J Gastroenterol. 2019 Sep 7; 25(33): 4805–4813. DOI: 10.3748/wjg.v25.i33.4805.
  17. Nirwan JS, Hasan SS, Babar ZU, Conway BR, Ghori MU. Global Prevalence and Risk Factors of Gastroesophageal Refux Disease (GORD): Systematic Review with Meta-analysis. Sci Rep. 2020; 10(1): 5814. DOI: 10.1038/s41598-020-62795.
  18. Fu S, Xu M, Zhou H, Wang Y, Tan Y, Liu D. Metabolic syndrome is associated with higher rate of gastroesophageal reflux disease: a meta-analysis. Neurogastroenterol Motil. 2022 May; 34(5): e14234. DOI: 10.1111/nmo.14234.
  19. Stepanov YuM, Zyhalo EV. Indices of heart rate variability for estimation of adaptive processes and stress resistance in gastroenterology practice (using up-to-date technology of precise-diagnosis). Gastroenterologìa. 2020; 54(2): 113–123. DOI: 10.22141/2308-2097.54.1.2020.206230. (In Ukrainian).
  20. Huang CC, Chan WL, Luo JC, et al. Gastroesophageal reflux disease and atrial fibrillation: a nationwide population-based study. PLoS One. 2012; 7(10): e47575. DOI: 10.1371/journal.pone.0047575.
  21. Wang L, Lu YW. Gastroesophageal reflux disease may causally associate with the increased atrial fibrillation risk: evidence from two-sample Mendelian randomization analyses. Front Cardiovasc Med. 2024 Jun 3; 11: 1393383. DOI: 10.3389/ fcvm.2024.1393383.
  22. Harada M, Van Wagoner DR, Nattel S. Role of inflammation in atrial fibrillation pathophysiology and management. Circ J. 2015; 79(3): 495–502. DOI: 10.1253/circj.CJ-15-0138.
  23. Floria M, Bărboi O, Grecu M, Cijevschi Prelipcean C, Balan G, Drug VL. Atrial fibrillation and sympathovagal balance in patients with gastroesophageal reflux disease. Turk J Gastroenterol. 2017 Mar; 28(2): 88–93. DOI: 10.5152/tjg.2017.16540.
  24. Linz D, Hohl M, Vollmar J, Ukena C, Mahfoud F, Böhm M. Atrial fibrillation and gastroesophageal reflux disease: the cardiogastric interaction. 2017 Jan; 19(1): 16–20. DOI: 10.1093/europace/euw092.
  25. Mohamed A, Ochoa Crespo D, Kaur G, et al. Gastroesophageal Reflux and Its Association with Atrial Fibrillation: A Traditional Review. Cureus. 2020, September 11; 12(9): e10387. DOI: 10.7759/cureus.10387.
  26. Gutierrez A, Van Wagoner DR. Oxidant and Inflammatory Mechanisms and Targeted Therapy in Atrial Fibrillation: An Update. J Cardiovasc Pharmacol. 2015 Dec; 66(6): 523–9. DOI: 10.1097/FJC.0000000000000313.
  27. Maruyama T, Fukata M, Akashi K. Association of atrial fibrillation and gastroesophageal reflux disease: Natural and therapeutic linkage of the two common diseases. J Arrhythm. 2018 Oct 12; 35(1): 43–51. DOI: 10.1002/joa3.12125.
  28. Lin K, Chen X, Zhang L, Wang Y, Shan Z. Proton pump inhibitors as also inhibitors of atrial fibrillation. Eur J Pharmacol. 2013 Oct 15; 718(1–3): 435–40. DOI: 10.1016/j.ejphar.2013.07.043. Epub 2013 Aug 21. PMID: 23973848.
  29. Jeremic N, Petkovic A, Srejovic I, Zivkovic V, Djuric D, Jakovljevic V. Effects of ischemia and omeprazole preconditioning on functional recovery of isolated rat heart. Rev Bras Cir Cardiovasc. 2015; 30: 266–275. DOI: 10.5935/1678–9741.20150020.
  30. Odashiro K, Yokoyama T, Yoda S, et al. Prevalence of gastroesophageal reflux disorder in аrrhythmic patients and adjunctive effects of proton pump inhibitors on comorbid atrial fibrillation. I J. Basic Clin. Pharmacol. 2015; 4: 644–650. https://doi.org/ 10.18203/2319-2003.ijbcp20150365.
  31. Prikhodko VYu, Moreva DYu. Features of the course and treatment of hypertension in combination with chronicis chemic heart disease in patients with gastroesophagel reflux disease. Famili medecine. 2016; 1(63): 65–70. https://doi.org/10.30841/ 2307-5112.1(63).2016.102165. (In Ukrainian).
  32. Chen CH, Lin CL, Kao CH. Association between gastroesophageal reflux disease and coronary heart disease: A nationwide populationbased analysis. Medicine (Baltimore). 2016; 95(27): e4089. DOI: 10.1097/MD.0000000000004089.
  33. Jagirdhar GSK, Bains Y, Surani S. Investigating causal links between gastroesophageal reflux disease and essential hypertension. World J Clin Cases. 2024 May 16; 12(14): 2304–2307. DOI: 10.12998/wjcc.v12.i14.2304.
  34. Oparin A, Vnukova A. The Role of Endothelial Dysfunction in the Mechanism of Gastroesophageal Reflux Disease Development in Patients with Ischemic Heart Disease. Acta Clin Croat. 2017 Dec; 56(4): 635–639. DOI: 10.20471/acc.2017.56.04.08.
  35. Song JH, Kim YS, Choi SY, Yang SY. Association between gastroesophageal reflux disease and coronary atherosclerosis. PLoS One. 2022 May 20; 17(5): e0267053. DOI: 10.1371/journal.pone.0267053.
  36. Liu Y, He S, Chen Y, et al. Acid reflux in patients with coronary artery disease and refractory chest pain. Intern Med. 2013; 52(11): 1165–71. DOI: 10.2169/internalmedicine.52.0031.
  37. Kato H, Ishii T, Akimoto T, Urita Y, Sugimoto M. Prevalence of linked angina and gastroesophageal reflux disease in general practice. World J Gastroenterol. 2009 Apr 14; 15(14): 1764–8. DOI: 10.3748/wjg.15.1764.
  38. Jansson C, Nordenstedt H, Wallander MA, et al. Severe symptoms of gastro-oesophageal reflux disease are associated with cardiovascular disease and other gastrointestinal symptoms, but not diabetes: a population-based study. Aliment Pharmacol Ther. 2008 Jan 1; 27(1): 58–65. DOI: 10.1111/j.1365-2036.2007.03537.x.
  39. Wu Q, He C, Huang W, et al. Gastroesophageal reflux disease influences blood pressure components, lipid profile and cardiovascular diseases: Evidence from a Mendelian randomization study. J Transl Int Med. 2024 Nov 6; 12(5): 510–525. DOI: 10.1515/jtim-2024-0017.
  40. Chen S, Chen Z, Jiang X, Lin C, Ji J. Modifiable risk factors mediate the effect of gastroesophageal reflux disease on stroke and subtypes: A Mendelian randomization study. J Stroke Cerebrovasc Dis. 2024 Apr; 33(4): 107612. DOI: 10.1016/ j.jstrokecerebrovasdis.2024.107612.
  41. Johansson S, Wallander MA, Ruigómez A, García Rodríguez LA. Is there any association between myocardial infarction, gastroesophageal reflux disease and acidsuppressing drugs? Aliment Pharmacol Ther. 2003 Nov 15; 18(10): 973–8. DOI: 10.1046/j.1365-2036.2003.01798.
  42. Carmona-Puerta R, Pérez-Sanchez D, Pichardo-Ureña JM, Rodríguez-Monteagudo JL, Lorenzo-Martínez E. The cardiovascular effects of large hiatal hernias: a narrative review of cases and studies. Postgrad Med. 2024 May; 136(4): 358–365. DOI: 10.1080/00325481.2024.2360886.
  43. Wei N, Liu MH, Song YH. Causal associations between gastroesophageal reflux disease and essential hypertension: A bidirectional Mendelian randomization study. World J Clin Cases. 2024 Feb 16; 12(5): 880–890. DOI: 10.12998/wjcc.v12. i5.880.
  44. Gridnyev AE. Comparative clinical and biochemical characteristics of hypertension and its comorbidity with gastroesophageal reflux disease. Ukrainskyi terapevtychnyi zhurnal. 2016; (2): 39–45. http://nbuv.gov.ua/UJRN/UTJ_2016_2_7. (In Russian).
  45. Prikhodko VYu, Moreva DYu. Feauturies of the course and treatment of hypertension in combination with chronicis ichemic heart disease in patients with gastroesophagel refluxdisease. Role of proton pump inhibitors test in the diagnosis and treatment of different forms of GERD. Famili medecine. 2016; 4: 75–80. https://family-medicine.com.ua/2412-8708/article/ view/248527/249650. (In Russian).
  46. Li ZT, Ji F, Han XW, Wang L, Yue YQ, Wang ZG. The Role of Gastroesophageal Reflux in Provoking High Blood Pressure Episodes in Patients with Hypertension. J Clin Gastroenterol. 2018 Sep; 52(8): 685–690. DOI: 10.1097/ MCG.0000000000000933.
  47. Gridnyev AE. Features of the daily profile of arterial pressure and geometry of the left ventricle in patients with a combination of gastroesophageal reflux disease and hypertension. Ukrainskyi terapevtychnyi zhurnal. 2015; (4): 40–46. http://nbuv.ua/UJRN/UTJ_2015_4_6. (In Russian).
  48. Meng D, Zhang X, Yu W, et al. Association between gastroesophageal reflux disease and stroke: a bidirectional Mendelian randomization study. Front Neurol. 2024 Jan 23; 14: 1295051. DOI: 10.3389/fneur.2023.1295051.
  49. Sohail R, Mathew M, Patel KK, et al. Effects of Non-steroidal Anti-inflammatory Drugs (NSAIDs) and Gastroprotective NSAIDs on the Gastrointestinal Tract: A Narrative Review. Cureus. 2023 Apr 3; 15(4): e37080. DOI: 10.7759/cureus.37080.
  50. Giudicessi JR, Ackerman MJ, Camilleri M. Cardiovascular safety of prokinetic agents: A focus on drug-induced arrhythmias. Neurogastroenterol Motil. 2018 Jun; 30(6): e13302. DOI: 10.1111/nmo.13302.
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