N 5 (196) 2025. P. 26–31

CLINICAL AND LABORATORY FEATURES OF THE FIRST HALF OF PREGNANCY DURING THE WAR IN UKRAINE

V. P. Mishchenko, V. V. Mishchenko

Odesa National Medical University, Odesa, Ukraine

DOI 10.32782/2226-2008-2025-5-4

Introduction. Chronic stress is a violation of the stress modulation system – a neuro-endocrine-metabolic reaction experienced by most young women today, which is associated with the war in Ukraine. The purpose of the study was to determine the features of the first half of pregnancy during the full-scale war in Ukraine and a personalized algorithm for managing women.

Materials and methods. We observed 30 women of reproductive age in the period of pregnancy from 5 to 20 weeks from the number of residents of the city of Odessa and the region, internally displaced persons.

Research results and discussion. The psycho-emotional state of the examined women was considered high. The patients were found to have high levels of specific total antibodies to the Helicobacter pillory antigen, pain in the lower back, thyroid disease. Late menarche was in 16.7%, early – in 13.3%, irregular menstrual cycle – in 23.3% of the examined women. Pregnant women were found to have uterine hypertonicity, partial detachment of the chorion, colpitis, cervical erosion. Low content and deficiency of vitamin D were determined.

Conclusions. During the full-scale war in Ukraine, every woman makes maximum efforts to preserve pregnancy. During the war years, artificial abortion is a negative trend. The frequency of stillbirths in the first trimester remains high. The features of pregnancy in the first half include: high psycho-emotional stress, chronic stress on the background of vitamin D hypovitaminosis, imbalance of the content of the trace element magnesium, cortisol, which requires timely personalized correction. We consider it appropriate to recommend determining the assessment of the psycho-emotional state of women at the stage of pregnancy planning and by trimesters, the levels of vitamin D, trace element magnesium, cortisol, progesterone and correction of their content using personalized micronutrient and drug therapy.

Keywords: clinical and laboratory features of pregnancy, war in Ukraine.

REFERENCES

  1. Вeery AK, Kaufer D. Stress, social behavior, and resilience: Insights from rodents. Neurobiology of Stress. Stress Resilience. 2015; 1: 116—127. DOI: 10.1016/j.ynstr.2014.10.004. ISSN 2352-2895. PMC 4281833. PMID 25562050.
  2. Bie L. The Status and Research Progres on Vitamin D. Deficiency and Atrial Fibrillation. Braz J Cardiovasc Surg. 2019; Dec 1; 34(5): 605–609. DOI: 10.21470/1678-9741-2018-0322.
  3. Carberg C. Vitamin D in the Cotext of Evolution. Nutrients. 2022; jul 22; 15(15): 3018. PMCID: PMC9332464. DOI: 10.3390/ nu14153018.
  4. Gutor TG, Timchenko NF. Epidemiolohichnyy analiz ta prohnoz nevynoshuvannya vahitnosti v Ukrayini ta Lvivskiy oblasti. [Epidemiological analysis and prognosis of miscarriage in Ukraine and Lviv region]. Klinichna ta profilaktychna medytsyna. 2023; 2: 38–44. (In Ukrainian) https://doi.org/10.31612/2616-4868.2(24).2023.06.
  5. Eyles DW. Vitamin D: Brain and Behavior. IBMR Plus. 2020 Oct 18; 5(1): e10419. DOI: 10.1002/jbm4.10419.
  6. Guideline 00503. Magnesium deficiency. 2018. http://guidelines.moz.gov.ua/documents/2918?id=ebm00503&Format=pdf (In Ukrainian).
  7. Lakhno IV. The level of pregnancy and childbirth complications among the residents of front-line city of Kharkiv. Journal of V. N. Karazin Kharkiv National University. Series ‘Medicine’. 2024; 32(3): 306–313. DOI: https://doi.org/10.26565/2313-6693-2024-50-03.
  8. Li X, Han X, Yang J, et al. Magnesium sulfate provides neuroprotection in eclampsia like seizure model by ameliorating neurosnflammation and brain edema. Neurobiol. 2017; 54 (10): 7938–7948. https://doi.org/10.1007/s12035-016-0278-4.
  9. Lovejoy DA, Barsyte D. Index. Sex, Stress and Reproductive Success. Chichester, UK: John Wiley & Sons, Ltd. 2011. DOI: 10.1002/9780470979600.index.
  10. Mishchenko VP, Mishchenko VV. Problema “operovanoyi matky” u suchasniy klinichnіy praktytsі (ohlyad literatury) [The problem of “operated uterus” in modern clinical practice (literature review)]. Visnyk problem biologii i medytsyny. 2024; 3(174): 50–63. (In Ukrainian). DOI: 10.29254/2077-4214-2024-3-174-50-63.
  11. Nakaz Ministerstva okhorony zdorovya No. 1437 vid 09.08.2022 “Normal’na vahіtnіst’”. (In Ukrainian). Available from: 39072-dn_1437_09_08_2022_dod_2.pdf.
  12. Sontia B, Touyz RM. Role of magnesium in hypertension. Arch Biochem Biophys. 2007 Feb 1; 458(1): 33–9. DOI: 10.1016/ j.abb.2006.05.005. PMID: 16762312.
  13. Thacher TD. Evaluating the Evidence in Clinical studies of Vitamin D in Covid-19. Nutrients. 2022 Jan 21; 14(3): 464. https://doi.org/10.3390/nu14030464.
  14. Zhabchenko IA. Mahnii v akusherskii praktytsi: vidomi fakty ta novi mozhlyvosti [Magnesium in obstetric practice: known facts and new opportunities]. Medychni aspekty zdorovia zhinky. 2019; 122–123(1–2): 32–38. (In Ukrainian). https://library. odmu.edu.ua/catalog/518822.
  15. Zmijewski MA. Vitamin D and Human Health. Int J Mol Sci. 2019; Jan 3; 20(1): 145. PMCID: PMC6337085. DOI: 10.3390/ ijms20010145.
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