N 5 (190) 2024. P. 45–50

FEATURES OF DESTRUCTIVE AND INFLAMMATORY PROCESSES OF THE ANTERIOR SURFACE OF THE EYE IN PATIENTS AFTER REMOVAL OF CEREBELLOPONTINE ANGLE TUMORS

V. M. Konakh, T. M. Komarova

Bogomolets National Medical University, Kyiv, Ukraine

DOI 10.32782/2226-2008-2024-5-7

The aim is to study changes in eye hydration and tear production in patients with lagophthalmos after removal of cerebellopontine angle (CPA) tumors and to identify correlations between levels of pro-inflammatory cytokines and proteolytic enzyme in tear fluid and the degree of corneal epithelial destruction.

Materials and methods. The study included 178 patients, 67 of whom had unilateral lagophthalmos after removal of CPA tumors.

Concentrations of IL-6, TNF-α, and MMP-9 gene expression in tear fluid were measured.

Results. A significant decrease in tear production and tear film stability, along with elevated levels of pro-inflammatory cytokines and proteolytic enzyme, was found. A correlation between MMP-9 levels and the degree of corneal epithelial damage was established.

Conclusions. In patients with lagophthalmos after removal of CPA tumors, there is a decrease in tear production and tear film stability, with elevated levels of pro-inflammatory cytokines and proteolytic enzyme.

Key words: cerebellopontine angle tumors, inflammation, cytokines, facial nerve, dry eye syndrome.

REFERENCES

  1. Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021; 71(3): 209–249. doi: 10.3322/caac.21660.
  2. Siegel RL, Miller KD, Fuchs HE, Jemal A. Cancer statistics, 2022. CA Cancer J Clin. 2022; 72(1): 7–33. doi: 10.3322/ caac.21708.
  3. CBTRUS Fact Sheet. Available from: https://cbtrus.org/cbtrus-fact-sheet/ (Last accessed: 11 June 2024).
  4. Ostrom QT, Price M, Neff C, et al. CBTRUS Statistical Report: Primary Brain and Other Central Nervous System Tumors Diagnosed in the United States in 2016–2020. Neuro Oncol. 2023; 25(12 Suppl 2): iv1–iv99. doi: 10.1093/neuonc/noad149.
  5. National Brain Tumor Society. Brain Tumor Facts. Available from: https://braintumor.org/brain-tumors/about-brain-tumors/ brain-tumor-facts/ (Last accessed: 11 June 2024).
  6. Siegel RL, Miller KD, Wagle NS, Jemal A. Cancer statistics, 2023. CA Cancer J Clin. 2023; 73(1): 17–48. doi: 10.3322/caac.21763
  7. Available from: http://www.ncru.inf.ua/publications/.
  8. Greene J, Al-Dhahir MA. Acoustic Neuroma. In: StatPearls. Treasure Island (FL): StatPearls Publishing; August 17, 2023.
  9. Foley RW, Shirazi S, Maweni RM, et al. Signs and Symptoms of Acoustic Neuroma at Initial Presentation: An Exploratory Analysis. 2017; 9(11): e1846. Published 2017 Nov 15. doi: 10.7759/cureus.1846
  10. Stangerup SE, Tos M, Thomsen J, Caye-Thomasen P. True incidence of vestibular schwannoma? 2010; 67(5): 1335–1340. doi: 10.1227/NEU.0b013e3181f22660.
  11. Reznitsky M, Petersen MMBS, West N, Stangerup SE, Cayé-Thomasen P. The natural history of vestibular schwannoma growth-prospective 40-year data from an unselected national cohort. Neuro Oncol. 2021; 23(5): 827–836. doi: 10.1093/ neuonc/noaa230.
  12. Tsymbaliuk VI, Konakh VM, Kiriiev VV, Vasiuta VA. Osoblyvosti tsytokinovoho profiliu sliznoi ridyny u khvorykh z urazhennyam lytsevoho nerva pislia vydalennia novoutvoren mosto-mozochkovoho kuta [Features of the cytokine profile of tear fluid in patients with facial nerve damage after removal of cerebellopontine angle tumors]. Skhidna Yevropa. 2013; 2: 35–41.
  13. Konakh VM. Osoblyvosti oftalmolohichnoi diahnostyky ta likuvannia urazhennia orhanu zoru u khvorykh z pukhlynamy mosto-mozochkovoho kuta. Dysertatsiia kand. med. nauk: 14.01.18. Nats. med. akad. pisliadyplom. osvity im. P.L. Shupyka [Features of Ophthalmological Diagnosis and Treatment of Eye Lesions in Patients with Cerebellopontine Angle Tumors. PhD Dissertation in Medical Sciences: 14.01.18. P.L. Shupyk National Medical Academy of Postgraduate Education]. Kyiv. 2015; 180.
  14. Lak AM, Khan YS. Cerebellopontine Angle Cancer. In: StatPearls. Treasure Island (FL): StatPearls Publishing; June 26, 2023.
  15. Chiu SJ, Hickman SJ, Pepper IM, Tan JHY, Yianni J, Jefferis JM. Neuro-Ophthalmic Complications of Vestibular Schwannoma Resection: Current Perspectives. Eye Brain. 2021; 13: 241–253. doi: 10.2147/EB.S272326.
  16. Gange WS, Kirchner ID, Thompson JA, et al. Ophthalmic Complications Following Acoustic Neuroma Resection. Oper Neurosurg (Hagerstown). 2018; 14(1): 58–65. doi: 10.1093/ons/opx071.
  17. Welder J, Allen R, Shriver E. Facial nerve palsy: ocular complications and management. 2024. Available from: http://EyeRounds.org/cases/215-facial-nerve.htm.
  18. Roy NS, Wei Y, Ying GS, Maguire MG, Asbell PA. Dry Eye Assessment and Management (DREAM) Study Group. Association of Tear Cytokine Concentrations with Symptoms and Signs of Dry Eye Disease: Baseline Data from the Dry Eye Assessment and Management (DREAM) Study. Curr Eye Res. 2023; 48(4): 339–347. doi: 10.1080/02713683.2022.2162088.
  19. Li M, Zhang L. IL-6 and TNF-α expression in the ocular surface of aqueous tear deficiency dry eye-type rat. Int J Ophthalmol. 2010; 10(7):1281–3. doi: 10.3969/j.issn.1672-5123.2010.07.013.
  20. Foulsham W, Mittal SK, Taketani Y, et al. Aged mice exhibit severe exacerbations of dry eye disease with an amplified memory Th17 cell response. Am J Pathol. 2020; 190(7): 1474–82. doi: 10.1016/j.ajpath.2020.03.016.
  21. Fortingo N, Melnyk S, Sutton SH, Watsky MA, Bollag WB. Innate Immune System Activation, Inflammation and Corneal Wound Healing. International Journal of Molecular Sciences. 2022; 23(23): 14933. doi: 10.3390/ijms232314933.
  22. Yagi Y, Andoh A, Inatomi O, Tsujikawa T, Fujiyama Y. Inflammatory responses induced by interleukin-17 family members in human colonic subepithelial myofibroblasts. J Gastroenterol. 2007; 42(9): 746–753. doi: 10.1007/s00535-007-2091-3.
View article PDF