N 4 (189) 2024. P. 25–28

THE COURSE OF METABOLIC COMPLICATIONS UNDER CHILDHOOD OBESITY AND OVERWEIGHT

I. Ye. Shapovalenko

Odesa National Medical University, Odesa, Ukraine

DOI 10.32782/2226-2008-2024-4-4

Іntroduction. Obesity is one of the greatest modern health problems among adults and children. Due to the constant significant increase in the prevalence of childhood obesity and overweight, the prevalence of comorbidities is also increasing. Childhood and adolescent obesity significantly raises the risk of cardiovascular disease and premature death, regardless of the presence of this disease and BMI level in adulthood. The metabolic complications of childhood overweight and obesity are asymptomatic and underdiagnosed conditions that lead to their progression and negative impact on the health of young adults.

The research aim is to analyze the course of metabolic complications of childhood obesity and overweight.

Materials and methods. The cohort non-intervention study involved 200 children aged 8 to 14 years with obesity criteria and overweight. Children were divided into comparison groups depending on their physical development. Group 1 included overweight children (133 children), and Group 2 included obese children (67 children). The criteria for exclusion from the study were the presence of infectious, endocrine, immune, and genetic diseases that could lead to liver damage.

Results and discussion. As a result of the assessment of all metabolic complications, a high incidence of metabolic-associated fatty liver disease (MAFLD) was found in both groups. Thus, it emphasizes the need to screen for these conditions and prevent the development of metabolic complications not only in obese but also in overweight children.

Conclusions. MAFLD is the most common and, at the same time, poorly studied pathology of the digestive system associated with obesity. Among the most frequent factors that may be associated with the development of metabolic complications in overweight and obese children, a group of factors related to early feeding and eating habits in the future, as well as a sedentary lifestyle, deserve attention. Metabolic-associated fatty liver disease occurs and requires treatment in both obese and overweight children.

Key words: children, obesity, overweight, liver, metabolic-associated fatty liver disease.

REFERENCES

  1. Abaturov AE, Nikulina AO. Metabolically associated fatty liver disease in children: educational and methodological guide. Dnipro: LIRA; 2021. 724 p. https://doi.org/10.22141/2224-0551.19.2.2024.1683 (Ukrainian)
  2. Eslam M, Sanyal AJ, George J; International Consensus Panel. MAFLD: A Consensus-Driven Proposed Nomenclature for Metabolic Associated Fatty Liver Disease. 2020;158(7):1999-2014.e1. doi: 10.1053/j.gastro.2019.11.312
  3. Abaturov O., Nikulina A. Metabolic dysfunction-associated fatty liver disease/metabolic dysfunction-associated steatotic liver disease: general provisions. CHILD`S HEALTH. 2024;19(2): 107–116. https://doi.org/10.22141/2224-0551.19.2.2024.1683 (Ukrainian )
  4. Chalasani N, Younossi Z, Lavine JE, et al. The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases. 2018;67(1):328–357. doi: 10.1002 / hep.29367
  5. Alisi A, Cianfarani S, Manco M, et al. Non-alcoholic fatty liver disease and metabolic syndrome in adolescents: pathogenetic role of genetic background and intrauterine environment. Ann Med. 2012;44(1):29-40. doi:10.3109/07853890.2010.547869
  6. Kryuchko TO, Pylypenko OA, Nesina IM, et al. Clinical and genetic aspects of non-alcoholic fatty liver disease in children with metabolic syndrome. International Journal of Pediatrics, Obstetrics and Gynecology. 2014;5(1):37-43 doi: 10.1016/j. jceh.2019.11.004 (Ukrainian)
  7. Ministry of Нealth of Ukraine. Order on September 24, 2022 No 1732. On Adoption of the Standards of Medical Care for Obesity in Children. https://moz.gov.ua/article/ministry-mandates/nakaz-moz-ukraini-vid-24092022–1732-pro-zatverdzhennja-standartiv–medichnoi-dopomogi-ozhirinnja-u-ditej Accessed: March 7, 2024. Ukrainian
  8. Vos MB, Abrams SH, Barlow SE, et al. NASPGHAN clinical practice guideline for the diagnosis and treatment of nonalcoholic fatty liver disease in children: Recommendations from the expert committee on NAFLD (ECON) and the North American Society of Pediatric Gastroenterology, Hepatology and Nutrition (NASPGHAN). J Pediatr Gastroenterol Nutr. 2017; 64:319. doi: 10.1097/MPG.0000000000001482
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