N 4 (189) 2024. P. 19–24

USE OF MINERAL WATER WITH HIGH ORGANIC SUBSTANCES IN EXPERIMENTAL METABOLIC SYNDROME

I. V. Smirnov, В. А. Nasibullin, S. G. Gushcha, A. L. Plakida

State Institution “Ukrainian Research Institute of Medical Rehabilitation and Resort Therapy of the Ministry of Health of Ukraine”, Odesa, Ukraine

Odesa National Medical University, Odesa, Ukraine

DOI 10.32782/2226-2008-2024-4-3

Introduction. Metabolic syndrome (MS) is considered a combination of several pathological processes – obesity, high blood pressure, dyslipidemia, carbohydrate metabolism disorder, and diabetes mellitus (DM), which determines the involvement of many functional systems of the body. One method for correcting metabolic disorders is crenotherapy, i.e., drinking various mineral waters (MW).

The research aims to determine experimentally the possibility of using MW with a high content of organic substances to restore the morpho-functional parameters of the body of a rat with a model of metabolic syndrome.

Materials and methods. Twenty-four rats were reproduced in the MS model using a high-glycemic load diet. After reaching the MS model, all rats were randomly divided into two groups of 12 animals each. All rats continued to receive the diet described above; however, the second (experimental) group also received intragastric MW with a high content of organic substances at a dose of 1% of body weight.

Results. The establishment of the MS model in rats is a crucial step, as it leads to significant functional disorders of the liver and kidneys. A comprehensive study of the histological structure of the liver and kidneys in rats with a model of MS revealed the dystrophic changes in hepatocytes and nephrons, underscoring the relevance of our research. MW treatment significantly improved the structural characteristics of the liver and kidney parenchyma of experiment rats. The level of endogenous intoxication normalized, and the water-electrolyte balance was restored.

Conclusions. Using a course of MW with an increased content of organic substances in rats with a metabolic syndrome model promotes the restoration of the structural organization of liver and kidney tissue, which leads to the normalization of the corresponding functional indicators. The obtained experimental results allow us to recommend the use of mineral waters with increased organic content for clinical studies in the rehabilitation of patients with metabolic syndrome.

Key words: metabolic syndrome, natural mineral water, liver, kidneys.

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