N 1 (186) 2024 р. P. 95–98

DOSE-DEPENDENT EFFECT OF HEXADECYL ESTER OF IBUPROFEN ON THE MODEL OF FORMALIN-INDUCED INFLAMMATION

B. V. Prystupa, S. I. Bogatu, V. Y. Kresyun, I. A. Boiko, L. M. Unhurian

Odesa National Medical University, Odesa, Ukraine

Introduction. Inflammation is a protective reaction of the organism to the damaging agent. Ibuprofen has anti-inflammatory, antipyretic, and anti-edema effect. But ibuprofen has also side effects.

The main goal was to estimate the “dose-effect” dependence of the hexadecyl ester of ibuprofen on the formalin model of inflammation.

Materials and methods. An acute inflammatory reaction was caused by the subplantar injection of 0.1 ml of 2% formalin into the hind limb of experimental rats. After the development of the inflammatory process, rats were treated by transdermal administration of the hexadecyl ester of ibuprofen as an ointment containing the ester in various concentrations – 5%, 2.5%, 1% and 0.5%. The dynamics of change in the inflammatory process determined by measuring the width and volume of the affected limbs.

Results. The hexadecyl ester of ibuprofen reduces the width and volume area of the inflammation in animals and has anti-inflammatory activity at the concentrations 0.5–5%.

Conclusion. The hexadecyl ester of ibuprofen demonstrated the high anti-inflammatory activity. The anti-inflammatory activity was not dependent from the concentration. It is advisable to use the 0.5% ointment of ibuprofen ester, which is almost equal in their efficiency to the 5% ointment.

Key words: pharmacological screening, anti-inflammatory effect, ibuprofen hexadecyl ether, dose-effect, formalin-induced inflammation.

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