N 4 (185) 2023. P. 61–68

CORRECTION OF LIPID METABOLISM DISORDERS IN THE COMPLEX TREATMENT OF YOUNG HYPERTENSIVE PATIENTS WITH OVERWEIGHT AND OBESITY

O. O. Yakymenko, K. S. Chernyshova, V. M. Bondar

Odessa National Medical University, Odesa, Ukraine

DOI 10.32782/2226-2008-2023-4-13

The purpose of the research is to improve the effectiveness of treatment in the correction of concomitant disorders of lipid metabolism in young patients with arterial hypertension and overweight or obesity using the controlled physical activity, calcium-enriched diet and correction of insulin resistance by metformin.

Materials and methods. 123 young patients, 18–44 years old, with essential arterial hypertension were examined and divided into 3 groups depending on the body mass index. The effectiveness of traditional antihypertensive and modified complex treatment in the correction of lipid metabolism disorders was assessed after 3, 6 and 12 months controlling the levels of total cholesterol, triglycerides, cholesterol of high-density lipoproteins, low-density lipoproteins, very low-density lipoproteins, non-high-density lipoproteins and coefficient of atherogenicity.

Results. The obtained results demonstrated a highly significant difference in favor of the effectiveness of the proposed treatment complex in the correction of lipid metabolism concomitant disorders and complex management of young hypertensive patients with overweight and concomitant obesity compared to traditional antihypertensive therapy, that improves the cardiovascular prognosis of this category of patients.

Key words: arterial hypertension, obesity, lipid metabolism, effectiveness of treatment, metformin.

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