N 3 (184) 2023. P. 76–83

TYPE 2 DIABETES MELLITUS: EPIDEMIOLOGY, COMPLICATIONS AND EARLY DIAGNOSIS

Odesa National Medical University, Odesa, Ukraine

DOI 10.32782/2226-2008-2023-3-14

The relevance of studying type 2 diabetes mellitus is associated both with its significant prevalence and the reduction in the quality of life, leading to severe diabetic complications that result in disability or mortality among people.

The aim of the study. To study the prevalence of type 2 diabetes, the influence of glycemia on the development of complications, and to determine the possibilities of early diagnosis of the disease.

Materials and methods. Contemporary domestic and foreign research have been studied and analyzed using available literary sources and electronic resources.

Research results. The article analyzes contemporary data on the incidence of type 2 diabetes mellitus. Diabetes remains one of the most prevalent diseases worldwide and significantly impairs the quality of life. It is associated with the development of complications, early disability, and premature mortality. Statistical data on the prevalence of the disease in recent years worldwide is provided. The link between the presence of diabetes and the development of severe complications is demonstrated. Diabetes contributes to the development of cardiovascular and cerebrovascular complications, is a cause of terminal renal failure, blindness, anemia, and increases the risk of lower limb amputation and many other lesions. The use of screening tests allows for the timely identification of individuals belonging to high-risk groups for the development of type 2 diabetes and for the early diagnosis of asymptomatic diabetes, which prevents the occurrence of severe complications and improves the prognosis and quality of life of patients.

Key words: diabetes mellitus, disease prevalence, diabetic complications, early diagnosis.

REFERENCES

  1. IDF Diabetes Atlas. 10th edition. 2021; Available from: https://diabetesatlas.org/.
  2. Heald AH, Stedman M, Davies M et al. Estimating life years lost to diabetes: outcomes from analysis of National Diabetes Audit and Office of National Statistics data. Cardiovasc Endocrinol Metab. 2020; 9:183–185.
  3. Hong Sun, Pouya Saeedi, Suvi Karuranga et al. IDF Diabetes Atlas: Global, regional and country-level diabetes prevalence estimates for 2021 and projections for 2045. Diabetes Research and Clinical Practice. 2022; 183. Available from: https:// doi.org/10.1016/j.diabres.2021.109119.
  4. Ogurtsova K, Guariguata L, Barengo NC et al. IDF Diabetes Atlas: Global estimates of undiagnosed diabetes in adults for 2021. Diabetes Research and Clinical Practice. 2022; 183: 109118. Available from: https://doi.org/10.1016/j. diabres.2021.109118.
  5. Bommer Сh, Sagalova V, Heesemann E et al. Global Economic Burden of Diabetes in Adults: Projections From 2015 to 2030. Diabetes Care. 2018; 41: 963–970. Available from: https://doi.org/10.2337/dc17-1962.
  6. Marcellusi A, Viti R, Sciattella P et al. Economic aspects in the management of diabetes in Italy. BMJ Open Diabetes Res Care. 2016; 4(1): 000197 DOI: 10.1136/bmjdrc-2016-000197.
  7. Public Health Center of the Ministry of Health of Ukraine. Available from: https://phc.org.ua/kontrol-zakhvoryuvan/ neinfekciyni-zakhvoryuvannya.
  8. Khyts A. School of endocrinologist: modern injection therapy of diabetes. Ukrainian Medical Journal. 2020; 1/1(135): 58–60 (In Ukrainian).
  9. American Diabetes Association Professional Practice Committee (2022) 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes. 2022 – Diabetes Care. 2022; 45(1): 17–38. Available from: https://doi.org/10.2337/ dc22-S002.
  10. Kaiser AB, Zhang N, Van Der Pluijm W. Global prevalence of type 2 diabetes over the next ten years (2018–2028). Diabetes. 2018; 67(1): 202. Available from: https://doi.org/10.2337/db18-202-LB.
  11. Hongjiang Wuю, Christopher C Patterson., Xinge Zhang. et al. Worldwide estimates of incidence of type 2 diabetes in children and adolescents in 2021. Diabetes Research and Clinical Practice. 2022; 185: 109785. Available from: https://doi. org/10.1016/j.diabres.2022.109785.
  12. Zelinska NB, Hryshchenko KV, Hloba YeV. Type 2 diabetes mellitus in children and adolescents in the world and in Ukraine. Ukrainian Journal of Pediatric Endocrinology. 2021; 1(37): 4–16 (In Ukrainian). Available from: https://doi.org/10.30978/ UJPE2021-1-4.
  13. Tuliantseva YeO, Velychko BI. Assessment of the quality of life of patients with type 2 diabetes. International scientific conference. 2022 July 29–30; Riga, the Republic of Latvia: 188–192 (In Ukrainian). Available from: https://repo.odmu.edu.ua:443/xmlui/handle/123456789/11624.
  14. Tronko MD, Bolshova OV, Sokolova LK, Belchina YuB. Type 2 diabetes mellitus: etiology, pathogenesis, clinic, diagnosis and treatment. Endoсrynologia. 2021; 10 (4): 35–44 (In Ukrainian).
  15. Centers for Disease Control and Prevention. National Diabetes Statistics Report, 2020: Estimates of Diabetes and Its Burden in the United States. Accessed 15 October 2020. Available from: https://www.cdc.gov/diabetes/pdfs/data/statistics/national- diabetes-statistics-report.pdf.
  16. Chung WK, Erion K, Florez JC et al. Precision Medicine in Diabetes: A Consensus Report From the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD). Diabetes Care. 2020; 43(7): 1617–1635 doi: 10.2337/dci20-0022.
  17. Musiienko VA, Marushchak MI. Genetic markers of type 2 diabetes. Medical and Clinical Chemistry. 2019; 21(4): 184-19 (In Ukrainian). DOI: https://doi.org/10.11603/mcch.2410-681X.2019.v.i4.10688.
  18. American Diabetes Association Professional Practice Committee (2022). 10. Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes–2022. Diabetes Care. 2022; 45(1): 144–174. Available from: https://doi.org/10.2337/ dc22-S010.
  19. American Diabetes Association Professional Practice Committee (2022). 12. Retinopathy, Neuropathy, and Foot Care: Standards of Medical Care in Diabetes–2022. Diabetes Care. 2022; 45(1): 185–194. Available from: https://doi.org/10.2337/ dc22-S012.
  20. Panina SS, Hondulenko NO, Sanina NA et al. Prevention and ways to reduce disability due to diabetes. Ukrainian Bulletin of Medical and Social Expertise. 2018; 3-4(29-30): 23–29 (In Ukrainian). Available from: http://nbuv.gov.ua/UJRN/ ujmse_2018_3-4_7.
  21. Cosentino F, Grant PJ, Aboyans V et al. 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD. European Heart Journal. 2020; 41(2): 255–323. doi: 10.1093/eurheartj/ehz486.
  22. Knuuti J, Wijns W, Saraste A et al. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. European Heart Journal. 2020; 41(3): 407-477 doi: 10.1093/eurheartj/ehz425.
  23. Ibanez B, James S, Agewall S et al. 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: the Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC). European Heart Journal. 2018; 39(2): 119-177 doi: 10.1093/eurheartj/ehx393.
  24. American Diabetes Association (2021). 11. Microvascular Complications and Foot Care: Standards of Medical Care in Diabetes-2021. Diabetes Care. 2021; 44(1): 151–167 doi: 10.2337/dc21-Srev.
  25. Fisher VL, Tahrani AA. Cardiac autonomic neuropathy in patients with diabetes mellitus: current perspectives. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy. 2017; 10: 419–434. Available from: https://doi.org/10.2147/DMSO. S129797
  26. Briukhova OV, Mankovsky BM. Structural changes of myocardium in patients with diabetes mellitus 2 type and cardiac autonomic neuropathy. Problems of Endocrine Pathology. 2018; 1:16-21 (In Ukrainian). Available from: https://doi. org/10.21856/j-PEP.2018.1.02.
  27. Serhiienko VO, Serhiienko OO. Diabetes mellitus and acute coronary syndromes. International Journal of Endocrinology. 2021; 7(4): 346-360 (In Ukrainian). Available from: https://doi.org/10.22141/2224-0721.17.4.2021.237351.
  28. American Diabetes Association Professional Practice Committee (2022). 11. Chronic Kidney Disease and Risk Management: Standards of Medical Care in Diabetes–2022. Diabetes Care. 2022; 45(1): 175–184 Available from: https://doi.org/10.2337/ dc22-S011.
  29. Ieromenko HV, Ospanova TS, Bezditko TV, Blazhko VI. Asthma and diabetes mellitus 2 type – polymorbidity of the XXI century. Asthma and Allergy. 2019; 1: 27-30 (In Ukrainian) DOI: 10.31655/2307-3373-2019-1-27-30.
  30. Sirchak YeS, Patskun SV. The frequency of Helicobacter pylori in patients with combination of the diabetes mellitus 2 type and chronic gastritis. Achievements of Clinical and Experimental Medicine. 2017; 2: 70–75 (In Ukrainian) doi 10.11603/1811-2471.2017.v0.i2.7653.
  31. Buzduhan IO, Fediv OI. Quality of life in patients with peptic ulcer ofthe stomach and duodenum in combination with hypertension and type 2 diabetes mellitus in the presence oftoxigenic (cagA+, vacA+) strains of Helicobacter pylori. Ukrainian Medical Journal. 2020; 2/6(140): 1-3 (In Ukrainian) DOI: 10.32471/umj.1680-3051.140.196155.
  32. Dynia YuZ. Clinical and pathogenetic features of intestinal lesions in patients with type 2 diabetes mellitus. Modern Gastroenterology. 2021; 5-6 (121-122): 30–36 (In Ukrainian). Available from: http://doi.org/10.30978/MG-2021-5-30.
  33. Dorofieiev AE, Shvets NI, Parkhomenko TA, Dynia YuZ, Chychula YuV. Diabetic enterocolopathy in patients with type 2 diabetes. International Journal of Endocrinology. 2019; 15(1): 61-65 (In Ukrainian).
  34. Aw W., Fukuda S. Understanding the role of the gut ecosystem in diabetes mellitus. Journal of Diabetes Investigation. 2018; 9:5–12. Available from: https://doi.org/10.1111/jdi.12673.
  35. Gerard C, Vidal H. Impact of Gut Microbiota on Host Glycemic Control. Endocrinol (Lausanne). 2019; 30:1–13. Available from: https://doi.org/10.3389/fendo.2019.00029.
  36. Gurung M, Li Zh, You H. et al. Role of gut microbiota in type 2 diabetes pathophysiology. 2020; 51:102590. Available from: https://doi.org/10.1016/j.ebiom.2019.11.051.
  37. Sirchak YeS, Sidei SM, Vais VV. Large intestine dysbiosis in patients with combination of diabetes mellitus type 2 and chronic noncalculous cholecystitis. Achievements of Clinical and Experimental Medicine. 2018; 2: 112-115 (In Ukrainian). DOI 10.11603/1811-2471.2018.v0.i2.8483.
  38. Klenovska SV, Shnaider SA, Maslov OV. Peculiarities of oral cavity microbiota changes in diabetes mellitus patients. Bulletin of Dentistry. 2019; 32(2): 29-33 (In Ukrainian) DOI 10.35220/2078-8916-2019-32-2-29-33.
  39. Setji T, Hopkins ThJ, Jimenez M. Rationalization, Development, and Implementation of a Preoperative Diabetes Optimization Program Designed to Improve Perioperative Outcomes and Reduce Cost. Diabetes Spectr. 2017; 30(3): 217–223. Available from: https://doi.org/10.2337/ds16-0066.
  40. Do DV, Han G, Abariga SA, Sleilati G, Vedula SS, Hawkins BS. Blood pressure control for diabetic retinopathy. Cochrane Database of Systematic Reviews. 2023; 3(3): 006127. Available from: https://doi.org/10.1002/14651858.CD006127.pub3
  41. Tarr JM, Kaul K, Chopra M, Kohner EM, Chibber R. Pathophysiology of Diabetic Retinopathy. ISRN Ophthalmology. 2013; 2013: 343560. DOI: 10.1155/2013/343560.
  42. Zherdova NM, Medvedovska NV, Makeiev SS, Mankovskyi BM. The relationship between diabetic retinopathy and cerebrovascular disease perfusion in patients with type II diabetes. Journal of Ophthalmology. 2018; 1(480): 49-53 (In Ukrainian).
  43. Garcia-Serrano AM, Duarte J. Brain Metabolism Alterations in Type 2 Diabetes: What Did We Learn From Diet-Induced Diabetes Models? Frontiers in neuroscience. 2020; 14: 229. Available from: https://doi. org/10.3389/fnins.2020.00229.
  44. Tumanskyi VO, Avramenko YuM. Pathomorphological changes of capillaries in the cerebral cortex in type 2 diabetes mellitus. Current issues in pharmacy and medicine: science and practice. 2021; 14(3): 354-362 (In Ukrainian) DOI:10.147 39/2409-2932.2021.3.244360.
  45. Pashkovska NV. Cognitive impairment in patients with type 2 diabetes mellitus: the role of hypoglycemic therapy. International journal of endocrinology. 2018; 14(1): 76-85 (In Ukrainian) DOI: 10.22141/2224-0721.14.1.2018.127097.
  46. Biessels GJ, Strachan MWJ, Visseren FLJ, Kappelle LJ, Whitmer RA. Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions. Lancet Diabetes Endocrinol. 2014; 2(3): 246–55 DOI: 10.1016/ S2213-8587(13)70088-3.
  47. Kondratenko AP. Cognitive and emotional disturbances of patients with type 2 diabetes mellitus. Experimental and Clinical Medicine. 2022; 4(89): 49-52 (In Ukrainian). Available from: https://doi.org/10.35339/ekm.2020.89.04.07.
  48. Shuprovych AA, Zinych OV. Nervous-mental stress and cognitive disorders as components of stress state in type 2 diabetic patients. Revie. Clinical endocrinology and endocrine surgery. 2022; 2(78): 61-68 (In Ukrainian). Available from: http://doi. org/10.30978/CEES-2022-2-61.
  49. Elsharkawy RE, Abdel Azim GS, Osman MA et al. Peripheral polyneuropathy and cognitive impairment in type II diabetes mellitus. Neuropsychiatr Disease and Treatment. 2021; 17: 627-635 doi: 10.2147/NDT.S284308.
  50. Duong V, Iwamoto A, Pennycuff J, Kudish B, Iglesia C. A systematic review of neurocognitive dysfunction with overactive bladder medications. Int Urogynecol J. 2021; 32(10): 2693-2702 doi: 10.1007/s00192-021-04909-5.
  51. Zherdova NM. Cognitive disorders in elderly patients with type 2 diabetes. The Health of Society. 2017; 6(1/2): 49–52 (In Ukrainian). Available from: http://nbuv.gov.ua/UJRN/zdc_2017_6_1-2_12.
  52. Munshi MN. Cognitive Dysfunction in older adults with diabetes: what a clinician needs to know. Diabetes Care. 2017; 40(4): 461-467 doi: 10.2337/ dc16-1229.
  53. Papathanasiou A, Koutsovasilius A, Shea S et al. The Problem Areas in Diabetes (PAID) scale: psychometric evaluation survey in a Greek sample with type 2 diabetes. J Psychiatr Ment Health Nurs. 2014; 21(4): 345-53 doi: 10.1111/j.1365-285 0.2012.01875.x.
  54. Shevchuk MV, Tsyhanenko OO, Taranenko OV, Kryzhevskyi VV, Mankovskyi BM. The practical importance of depression diagnosis in type 2 diabetes mellitus patients. International journal of endocrinology. 2019; 15(1): 50-54 (In Ukrainian). doi: 10.22141/2224-0721.15.1.2019.158695.
  55. Velychko VI, Nikitina VI, Said EV, Amirova AYu. The psychological and emotional state of patients with type 2 diabetes mellitus on the background of excessive body weight. Journal of Education, Health and Sport. 2017; 7(3): 531-539. Available from: http://dx.doi.org/10.5281/zenodo.495479.
  56. Ameres M, Brandstetter S, Toncheva AA et al. Association of neuronal injury blood marker neurofilament light chain with mild-to-moderate COVID-19. Journal of Neurology. 2020; 267(12): 3476–3478 doi: 10.1007/s00415-020-10050-y
  57. Kanberg N, Ashton NJ, Andersson LM et al. Neurochemical evidence of astrocytic and neuronal injury commonly found in COVID-19. 2020; 95(12): 1754-1759 doi: 10.1212/WNL.0000000000010111.
  58. Taquet M, Luciano S, Geddes JR, Harrison PJ. Bidirectional associations between COVID-19 and psychiatric disorder: retrospective cohort studies of 62,354 COVID-19 cases in the USA. Lancet Psychiatry. 2021; 8(2): 130-140 DOI: 10.1016/ S2215-0366(20)30462-4.
  59. Guo W, Li M, Dong Ya et al. Diabetes is a risk factor for the progression and prognosis of COVID-19. Diabetes Metabolism Research and Reviews. 2020; 36(7): 3319. Available from: https://doi.org/10.1002/dmrr.3319.
  60. Guan W-jie, D Ph, Ni Zh-yi et al. Clinical characteristics of coronavirus disease 2019 in China. New England Journal of Medicine. 2020; 382: 1708-1720 doi:10.1056/NEJMoa2002032.
  61. Li B, Yang J, Zhao F et al. Prevalence and impact of cardiovascular metabolic diseases on COVID-19 in China. Clinical Research in Cardiology. 2020; 109: 531-538 doi:10.1007/s00392-020-01626-9.
  62. Yan Y, Yang Y, Wang F et al. Clinical characteristics and outcomes of patients with severe COVID-19 with diabetes. BMJ Open Diabetes Res Care. 2020; 8(1): 001343 doi: 10.1136/bmjdrc-2020-001343.
  63. Shenoy A, Ismaily M, Bajaj M. Diabetes and Covid-19: a global health challenge. BMJ Open Diabetes Res Care. 2020; 8(1): 001450 doi:10.1136/ bmjdrc-2020-001450.
  64. Zhao Zh, Wang Sh, Ma W et al. Diabetes mellitus increases the incidence of deep vein thrombosis after total knee arthroplasty. Archives of Orthopaedic and Trauma Surgery. 2014; 134(1): 79-83 doi: 10.1007/s00402-013-1894-3.
  65. Urbanovych AM, Dunets YuV. Peculiarities of the course of anemic syndrome in patients with diabetes mellitus. 2021; 26(1): 75-81 (In Ukrainian). DOI: 10.31793/1680-1466.2021.26-1.75.
  66. Yang W, Cai X, Wu H, Ji L. Associations between metformin use and vitamin B12 levels, anemia, and neuropathy in patients with diabetes: a meta-analysis. Journal of Diabetes. 2019; 11(9): 729-743 doi: 10.1111/1753-0407.12900.
  67. Bell DSH. Metformin-induced vitamin B12 deficiency can cause or worsen distal symmetrical, autonomic and cardiac neuropathy in the patient with diabetes. Diabetes Obes Metab. 2022; 24(8): 1423-1428 doi: 10.1111/dom.14734.
  68. Tykhonova TM, Smilka YuM. Diabetic polyneuropathies: options of the course and influence on the quality of patients’ life. Problems of Endocrine Pathology. 2019; 69(3): 144-148 (In Ukrainian). Available from: https://doi.org/10.21856/j-PEP.2019.3.19.
  69. Pop-Busui R, Boulton AJM, Feldman EL et al. Diabetic Neuropathy: A Position Statement by the American Diabetes Association. Diabetes Care. 2017; 40(1): 136–154. Available from: https://doi.org/10.2337/dc16-2042.
  70. Cignarelli А, Genchi VA, Caruso I et al. Diabetes and cancer: pathophysiological fundamentals of a ‘dangerous affair’ Diabetes Res Clin Pract. 2018; 143: 378–388 DOI: 10.1016/j.diabres.2018.04.002.
  71. Zhuravlova LV, Sokolnikova NV. The diabetes mellitus and oncopathоlogy. Medicines of Ukraine. 2021; 2 (248): 32-40 (In Ukrainian). Available from: https://doi.org/10.37987/1997-9894.2021.2(248).229022.
  72. Velychko VI, Mykhailenko VL, Lahoda DO, Volokhova HO, Lyashenko SL. Screening for diabetes and prediabetes: new communication opportunities. Reproductive endocrinology. 2021; 5(61): 92-95 (In Ukrainian). Available from: http://dx.doi. org/10.18370/2309-4117.2021.62.92-95.
  73. Velychko VI, Said OV, Kolotvina LI, Karpynska TL, Astvatsatrian HR. Results of screening for disorders of carbohydrate metabolism and type 2 diabetes among Odesa residents. Family medicine. 2015; 5: 132-134 (In Ukrainian).
  74. Chadha Ch, Pittas AG, Lary ChW et al. Reproducibility of a prediabetes classification in a contemporary population. Metabol Open. 2020; 6: 100031 DOI: 10.1016/j.metop.2020.100031.
  75. American Diabetes Association Professional Practice Committee (2021) 2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes. 2021 – Diabetes Care. 2021; 44(1): 15-33 DOI: 10.2337/dc21-S002.