The present work is dedicated to the phenazepam pharmacokinetics studying after transdermal administration depending on its dose in TTS. The data obtained are evidence that TTS maintains the drug concentraton in the organism on the steady level during the application time. On the base of the experimental data the pharmacokinetic phenazepam parameters depending upon the dose in the TTS applied after its transdermal administration were determined. It was shown that with dose increase in the TTS the drug bioavailability decrease occurs. It is explained by the phenazepam flow maximal value achieving.
