A Non-syndromal or orofacial upper lip and/or palate cleft (LPC) is a consequence of embryogenesis violation (nonunion of nasal process and/or palatal prominence). Non-syndromal LPC include two independent pathologies: congenital combined cleft of the upper lip and/or palate (LPC) and congenital cleft of palate (PC). In LPC some locuses on chromosomes were identified, and a specific gene is found in one case. In the isolated clefts of the palate one gene was also identified, but, probably, a more considerable amount of genes are engaged in a defect’s formation.
