Odesa National Medical University MH of Ukraine, Odesa, Ukraine
DOI 10.54229/2226-2008-2021-6-3
The article deals with the relationship between the histamine intolerance syndrome (HIS) and chronic urticaria (CU).
We conducted a comprehensive examination of 38 patients with chronic urticaria and determined their level of diaminoxidase (DAO), the main enzyme involved in the degradation of histamine. It was found that the frequency of HIS in patients with CU was 89.5%. A significant number of patients (63.2%) had the background of sensitization. It was established that HIS plays a certain role in the development of CU, acting as a factor aggravating the course of the disease. The value of the DAO level should be taken into account during prescribing the complex therapy for patients with CU. The diagnostic evaluation of the determination of DAO in patients with CU requires further study, especially when the negative markers for the development of allergic reactions are identified.
Key words: chronic urticaria, histamine intolerance syndrome, diaminoxidase.
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