The data of the experimental trials are given devoted to interleukin-1 (IL-1) receptors block through recombinant antagonist of IL-1 receptors (RAIL) influence on acute generalized, kindled seizures and postkindling. Interleukin receptors block was shown to induce the anticonvulsive effect. RAIL anticonvulsive effect was expressed by seizure intensity and number of rats with generalized clonic-tonic convulsions decrease, first convulsions latency increase in conditions of acute generalized, kindled seizures induced by picrotoxine and postkindling. Nucleus ambiquus destruction results in the RAIL anticonvulsive effect complete elimination, RAIL anticonvulsive effect was partially blocked by both black substance reticular and compact parts destruction that revealed direct cholinergic mechanisms participation in the abovementioned effect realization.
The conclusion is made about cytokines pathogenetic role in epileptogenesis that is an experimental background of possible anticonvulsive effect in case of interleukin receptors blockade.