The result of the largest international multicentral researches are presented in the review, showing diminution of lethality after giving thrombolytic therapy to the patients suffering from myocardial infraction. The causes limiting efficiency of thrombolysis are analysed, the modern noninvasive criteria of reperfusion are presented, the temporary intervals of its conduction, results of the modern researches on camparative efficiency of thrombolytic agents and perspective ways of optimization of thrombolytic therapy are recommended.
