Introduction. The main standard method of therapy of multiple sclerosis (MS) is the use of schemes of intravenous corticosteroids in pulse doses. Additional application of components of neuroprotective-antioxidant complex contributes to the inhibition of the progression of MS, slowing down the rate of apoptosis of neurons and oligodendrocytes, as well as reducing the intensity of the myelin damage.
The aim of the work. A comparative analysis of the effects of citicoline, a-lipoic acid, nicergoline and donepezil on locomotor and research activity of rats in the test “open field” in terms of experimental allergic encephalomyelitis (EAE).
Methods. The research was conducted on 42 white rats divided randomly into 7 groups. The drugs were injected intragastrically once a day on the background of basic therapy with Solu-Medrol from the 2nd on the 16th day after the induction of EAE (latent phase + clinical phase of the disease). Test of motility and emotional condition on the last day of drug administration in all experimental groups was determined by the number of crossed squares (horizontal activity), vertical lifts and studies of holes (research activity), as well as the duration of the acts of grooming and the number of defecation boluses (emotional state) for 3 min.
Results. drugs of neuroprotective-antioxidant complex normalize impaired motor and exploratory activity of rats: drugs statistically significantly increased the number of horizontal transitions, studies of holes and the number of vertical lifts on average 70% (p<0.01), 80% (p<0.05) and 100% (p<0.05) respectively compared to animals with EAE. the ability to restore locomotor and research activity in the conditions of the experimental equivalent of multiple sclerosis decreases in the number of citicoline (500 mg/kg) > a-lipoic acid (50 mg/kg) » nicergoline (10 mg/kg) >> donepezil (10 mg/kg).
Conclusion. Administration of neuroprotective-antioxidant complex on a background of hormonal therapy restores all indicators about the research activity of rodents in terms of EAE.