We investigated the anti-inflammatory activity of ibuprofen esters on the formalin-induced paw edema in rats as a model of chronic inflammation. Acute inflammatory reaction was induced by injecting 0.1 ml of 2% formalin into the sub planter area of the right hind paw of anaesthetized rats. After 3 days after administration of formalin was carried out observing the functional state of the animals during 12 days.
Ibuprofen and its esters administered orally in equimolar doses, corresponding to 15 mg/kg ibuprofen in the twin-80 emulsions and transdermally — in the form of 5% cream. Determination of anti-inflammatory activity was based on the setting of the dynamics of the width and volume of affected limbs of rats. Degree of inflammation was measured plethysmometrically and digital caliper every days.
Esters of ibuprofen have a high anti-inflammation and anti-edema activity by the oral and transdermal administration which had in the equimolar amounts more than ibuprofen efficiency.
The best activity was defined for hexadecyl ether. Oral and transdermal administration leads to narrowing of the affected limbs after formalin-induced paw edema. Return to baseline levels has been observed on the 11th day of the treatment process of inflammation.