The role of gastrin in the origin of pathology of gastrointestinal tract is determined; gastrin influences the level of the stomach рН; with age its production is increased under influence of the insulin, free amino acid and hypercalciemia. Influence of other substances on the gastrin level is determined: prostaglandin E, endorfins and calcitonin supress the secretion of gastrin; on the contrary, after the vagotomy the level of gastrin in the blood grows. The secretion of gastrin is increased by stress and high level of glucocorticoids.
Change in the amount of gastrin in the blood — is a measure that determines the gastro-intestinal tract (gastrinoma, gastric cancer, pernicious anemia, atrophic gastritis). The duodenal bile reflux can stimulate gastrin secretion, at gastritis-reflux content of basal gastrin in the blood serum increases 3 times or more, and with the aggravation of gastric ulcer its content also increases.
The growth of gastrin level may be the reason of the stomach cancer development. Chronic inflammation of the colon causes polyps. Demonstration of the ability of gastrin cause degeneration of polyps to adenomas, which may become malignant formation. Gastrin can enhance invasiveness of malignant tumors and their metastases. Development of cancerous tumors promotes both high and low levels of gastrin.
Therefore it is shown a direct relationship between acidity of gastric juice and morphological changes in the mucosa of the stomach and colon, which are caused by hypergastrinemia, all of which will develop effective methods for the prevention of recurrence of polyps and prevent their degeneration and determine the prospects of our research. It is shown a direct connection between the acidity of gastric juice and morphological changes in the mucosa of the stomach and large intestine (including polyps), which are caused by hypergastrinemia.