CHEMISTRY OF N-SUBSTITUTED MALEINIMIDES AND BIOLOGICAL ACTIVITY OF THEIR NEW DERIVATIVES

A new method of synthesis for the preparation of original derivatives of N-substituted maleinimides with participation of 2-mercaptobenzoic acid at the solvents system (benzene–pyridine), with temperature 60–80°С and mixing of reaction mixture from 3 to 7 h, with next treating of reaction products by ethanol in water solution (1:1) and dry benzene was described.
It was discovered that derivatives of N-substituted maleinimides, which synthesized applies to a little toxic preparations.
New derivatives of N-substituted maleinimides with potential biological activity have pharmacaphoric groups in molecules and can be perspective in elaboration of potential medical drugs.