Аналіз складу конденсату вологи видихуваного повітря у дітей, хворих на бронхіальну астму

Abstract

Статья посвящена изучению макромолекулярного состава конденсата влаги выдыхаемого воздуха у детей, больных бронхиальной астмой, с использованием метода лазерной корреляционной спектроскопии. Проведен анализ перераспределений выдыхаемых частиц в спектре конденсата и изучены патофизиологические процессы при заболевании бронхиальной астмой.

Attention is currently drawn to the method of analysis of exhaust air condensate, which allows assessing the state of the respiratory system and the nature of the inflammatory process. The aim of the study is to determine and analyze the composition of the moisture condensation of the exhaled air in children with bronchial asthma. Materials and methods. With the purpose of determining the composition of the condensation of the moisture of the exhalated air in the respiratory tract, 41 children 8 to 10 years old with asthma admitted to a hospital with this diagnosis were examined. The investigations were carried out using the method of laser correlation spectrometry. Conclusion. The presence in the spectrum of condensation of particles in the sizes of 2 nm, 26– 290 nm, and a small number of particles in the range of 3–6 nm allows to establish in the surveyed group of children with bronchial asthma some changes in the functioning of the respiratory system. The appearance of a condensation spectrum in the size from 26 nm to 290 nm shows an increase in the number of high-density lipoprotein and lipoprotein, as well as immune complexes. In patients with bronchial asthma in the bronchial secretion, there was a decrease in IgA and IgG, corresponding to particles in the range of sizes from 3 nm to 6 nm. Detection of a number of particles of large size is associated with the appearance of fragments of cell disintegration.