Сравнительная оценка клинической эффективности различных комбинаций антигипертензивных препаратов в терапии резистентной артериальной гипертензии

Abstract

60 patients with the resistant arterial hypertension of the 2" degree at the age of 45 to 74 years were examined. Depending on the undergone treatment all the patients were divided into two groups. The patients of the control group got Amlodipine, Lisinopril, Hydrochlorothiazide in maximum tolerable doses, the patients of the main group took the average therapeutic doses of these preparations and Urapidil in addition. The dynamics of the complaints, the indices of the office ABP, ECG, laboratorial analyses (ALT, AST, creatinine, uric acid) were estimated in all patients. More expressed positive dynamics of the subjective indices, i.e. the shortening of the complaints about precordialgiae, exertional dyspneae in number, was observed in the patients from the main group. But in the control group the number of the complaints about headaches grew, the ones about cough, nausea appeared. Only in the main group the average ABP almost achieved its goal and made 143.8/89.6 mm Hg. In the whole, the achievement of the goal ABP was noticed in the main group in 21 patients and in 8 ones from the conirol group. The improvement in the processes of repolarization was observed in the patients from the main group more often than in the patients from the control one: the growth of the T wave amplitude occurred, reduction in the frequency of the revelation of isoelectric T wave happened.The combined therapy with the application of Urapidil has allowed the achievement of the goal ABP at the fewer side effects in the most of the patients.