Abstract:
The purpose of the study was to study the dynamics of foci of epileptic activity, which
were reproduced in the cerebral cortex of kindled rats using the sodium salt of
benzylpenicillin, under the conditions of individual and combined use of pioglitazone and
thioperamid. Under conditions of acute observation in rats kindled with pentylenetetrazole
repeated administration (30-35 mg/kg, i.p.), the influence of thioperamid (2,5 and 15,0 mg/kg,
i.p.) and pioglitazone(50,0 and 200,0 mg/kg, i.p.) administrations upon penicillin-induced foci
in the frontal cortex have been investigated. The data obtained showed that pioglitazone use
in a previously ineffective dose (50.0 mg/kg, i.p.) but against the background of the
administration of thioperamid (2.5 mg/kg, i.p.) was accompanied by the development of an
anticonvulsant effect, which was expressed as inhibition of the amplitude and frequency of
epileptic seizures potentials, as well as in reducing the life span of epileptic foci. A similar
result indicates the possibility of restoration of sensitivity to the anticonvulsant effects of the studied drugs when they are used together in kindling provoked resistance to the action of
antiepileptic drugs. Thus, the development of the antiseizure effect of thioperamid and
pioglitazone, which were used in initially not effective dosages (2,5 and 50,0 mg/kg
correspondently), have been described. This fact favors the synergy of the antiepileptic action
of investigated compounds.
