In order to assess the quality of life for patients with atrial fibrillation (AF) before and after pulmonary veins isolation (PVI) there were examined 143 patients with AF refractory to conservative antiarrhythmic therapy. It was shown reliable improvement in quality of life of patients with AF after the PVI. Individual analysis of the quality of life in 6 months showed that after PVI improvement of this index was in 124 (86.7%) of 143 patients, no change — in 11 patients (7.7%), deterioration — in 4 (2.8%).