N 2 (183) 2023. P. 108–110

METHOD AND DEVICE FOR SHOCK WAVE MODELING (LITERATURE REVIEW)

Dnipro State Medical University, Dnipro, Ukraine

DOI 10.32782/2226-2008-2023-2-20

The widespread use of explosive devices in military conflicts leads to an increase in blast injuries to organs, which differ from classic mechanical injuries by the mechanism of damage and clinical signs. The special attention of both clinicians and theoreticians is attracted by blast brain traumatic injury, since its course is distinguished by the appearance of cognitive-behavioral disorders in an acute period and the development of neurodegeneration in the remote period. However, the pathogenesis is currently largely undisclosed, and all experimental studies differ in modeling methods. So, we made an analysis of modern literature in order to establish the differences between devices for creating an explosive wave and, taking into account the advantages and disadvantages, we proposed our own device, which is safe and guaranteed to generate an explosive wave of the pressure necessary for damage.

Key words: blast injury, device, experiment, brain.

REFERENCES

  1. Kazennikov ОV, Manukhin IB, Petrov КА. Explosive brain injury: injury mechanisms, clinical manifestations, diagnosis and therapeutic approaches. Neuroscience and behavioral physiology. 2017; 47(5): 552–563. doi: 10.1007/s11055-017-0485-9. PMID: 28429148 (in Ukranian).
  2. Mamedov ShM, Tkachenko OV, Kozlov SV, Vydysh KP, Kozlova JuV. Lysycja OC. Pathomorphological aspects of vibukhovoy injuries (a specific characteristic of the ears, caused by the opposite ulamkovy mines OZM-72 and MON-50). Sudovo-medychna ekspertyza. 2017; (1): 102–106 (in Ukraіnian).
  3. Ling G, Ecklund JM, Bandak FA. Brain injury from explosive blast: description and clinical management. Handbook of Clin Neurol. 2015; 127: 173–80. doi: 10.1016/B978-0-444-52892-6.00011-8.
  4. Nguyen T, et al. Experimental platforms to study blast injury. BMJ Military Health. 2019; 165: 33–37.
  5. Lukianova LD, Koriakina LА. Experimental modeling of blast-induced traumatic brain injury. Bulletin of experimental biology and medicine. 2018; 165(4): 528–531. (in Ukraіnian).
  6. Matsuura H, et al. Original experimental rat model of blast-induced mild traumatic brain injury: a pilot study. Brain Inj. 2021; 35(3): 368–381.
  7. Clemedson CJ, Criborn CO. A detonation chamber for physiological blast research. J Aviat Med. 1955; 26: 373–381.
  8. Goldstein LE, McKee AC, Stanton PK. Considerations for animal models of blast-related traumatic brain injury and chronic traumatic encephalopathy. Alzheimers Res Ther. 2014; 6(5): 64. doi: 10.1186/s13195-014-0064-3. PMID: 25478023; PMCID: PMC4255537.
  9. Courtney A, Courtney M. The complexity of biomechanics causing primary blast-induced traumatic brain injury: A Review of Potential Mechanisms. Front Neurol. 2015; 6: 221. doi: 10.3389/fneur.2015.00221. PMID: 26539158; PMCID: PMC4609847.
  10. Liu M, et al. A novel rat model of blast-induced traumatic brain injury simulating different damage degree: implications for morphological, neurological, and biomarker changes. Front Cell Neurosci. 2015; 9: 168. doi: 10.3389/fncel.2015.00168. PMID: 25983677; PMCID: PMC4416450.
  11. Unnikrishnan G., et al. Animal Orientation affects brain biomechanical responses to blast-wave exposure. J. Biomech. Eng. 2021; 143(5): 051007. doi: 10.1115/1.4049889. PMID: 33493319.
  12. Cernak I, et al. The pathobiology of blast injuries and blast-induced neurotrauma as identified using a new experimental model of injury in mice. Neurobiol Dis. 2011; 41(2): 538–51. doi: 10.1016/j.nbd.2010.10.025.
  13. Kawa L, et al. A comparative study of two blast-induced traumatic brain injury models: changes in monoamine and galanin systems following single and repeated exposure. Frontiers in neurology. 2018; 9: 479. doi: 10.3389/fneur.2018.00479.
  14. Zhang L, Jackson WJ, Bentil SA. Deformation of an airfoil-shaped brain surrogate under shock wave loading. J. Mech. Behav. Biomed. Mater. 2021; 120:104513. doi: 10.1016/j.jmbbm.2021.104513. Epub 2021 May 12. PMID: 34010798.
  15. Sundaramurthy A, et al. Blast-induced biomechanical loading of the rat: an experimental and anatomically accurate computational blast injury model. J. Neurotrauma. 2012; 29(13): 2352–64. doi: 10.1089/neu.2012.2413. Epub 2012 Jul 10. PMID: 22620716.
  16. Kozlova YuV, et al. [Device for studying the effect of the shock wave of an explosion on the body]. Ukraine patent No. 146858. 2021. Available from: https://base.uipv.org/searchINV/search.php?action=viewdetails&IdClaim=275098 (in Ukraіnian).