N 2 (183) 2023. P. 26–30

THE RELATIONSHIP BETWEEN THE EXPRESSION OF MICRORNA-29B AND -146A WITH CLINICAL AND PATHOLOGICAL CHARACTERISTICS OF PATIENTS WITH UTERINE FIBROIDS

I. Z. Gladchuk, N. M. Rozhkovska, O. S. Saleh

Odesa National Medical University, Odesa, Ukraine

DOI 10.32782/2226-2008-2023-2-4

In order to investigate the relationship between the expression of miRNA-29b and -146a and the clinical and pathological characteristics of patients with uterine myoma, 28 patients with uterine myoma were examined, in whom the expression of miRNA in tumor tissue was determined using polymerase chain reaction (PCR) in real time.

Analysis of miRNA-29b and -146a expression levels in the tumor tissue of patients with uterine fibroids, establishing their significant variability. The average expression level of microRNA-29b was 4.6±0.5 units, miRNA-146a – 52.0±4.8 units. A direct correlation between body mass index (BMI) and miRNA-29b and miRNA-146a expression was established (p<0.05), as well as miRNA-29b expression and uterine vessel dopplerometry indicators (p<0.05). However, an inverse correlation of miRNA-146a expression with the resistance index (p<0.05) and the pulsatility index of the node (p<0.05) was found in the myomatous node tissue.

Key words: uterine fibroids, epigenetics, biomarkers of prognosis, miRNA, diagnostics.

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