N 1–2 (179–180) 2022. P. 49–53

ANALYSIS OF SEASONAL FLUCTUATIONS OF VITAMIN D LEVELS IN RESIDENTS OF SOUTHERN REGIONS OF UKRAINE DEPENDING ON GENDER AND AGE

Odessa National Medical University, Odesa, Ukraine,
Odessa I. I. Mechnikov National University, Odesa, Ukraine

DOI 10.54229/2226-2008-2022-1-2-9

According to the WHO, the prevalence of vitamin D deficiency has reached the level of a global pandemic. Despite the fact that deficiency and insufficiency of vitamin D are noted in various population groups all over the world, there are quite limited data on the status of 25(OH)D blood serum among residents of the Southern regions of Ukraine, who live in conditions of sufficient insolation.

The purpose of the study was to analyze the prevalence of vitamin D deficiency in residents of Southern Ukraine, depending on the season. In the course of the study, 928 residents of the Southern region of Ukraine aged from 19 to 82 were examined. The study took place during a calendar year, which made it possible to evaluate the fluctuations of the 25(OH)D level in different months with different duration of insolation. The prevalence of deficiency, insufficiency and sufficient level of vitamin D in the study group was 33.6%, 33% and 33.4%, respectively. Fluctuations in 25(OH)D levels depending on the season of the year are described.

The results obtained in the course of the study contradict a previous study conducted in Ukraine, which recorded a higher prevalence of vitamin D deficiency states, but confirms the majority of regional European studies that reflect the status of 25(OH)D in blood serum.

Key words: vitamin D deficiency, vitamin D insufficiency, prevention, risk factors, population of Ukraine.

REFERENCES

  1. Sassi F., Tamone C., D’Amelio P. Vitamin D: Nutrient, Hormone, and Immunomodulator. Nutrients. 2018. 10:1656. DOI: 10.3390/nu10111656. URL: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6266123/.
  2. Roth D.E., Abrams S.A., Aloia J., Bergeron G., Bourassa M.W., Brown K.H., Calvo M.S., Cashman K.D., Combs G., De-Regil L.M., et al. Global prevalence and disease burden of vitamin D deficiency: A roadmap for action in low- and middle-income countries. Ann. N. Y. Acad. Sci. 2018. 1430:44–79. DOI: 10.1111/nyas.13968.
  3. Shanyhin A. The significance of diet and insolation levels in vitamin D supply. Modern aspects of prevention. Health of Society. 2022. 11:16-22. https://doi.org/10.22141/2306-2436.11.1.2022.288 (in Ukrainian).
  4. Gibbons J.B., Norton E.C., McCullough J.S. et al.Association between vitamin D supplementation and COVID-19 infection and mortality. Sci Rep.12, 19397. 2022. URL: https://doi.org/10.1038/s41598-022-24053-4.
  5. Amrein K., Scherkl M., Hoffmann M., Neuwersch-Sommeregger S., Köstenberger, M., Tmava Berisha A., Martucci G., Pilz S., & Malle O. Vitamin D deficiency 2.0: an update on the current status worldwide. European Journal of clinical nutrition, 2020. 74(11), 1498–1513. URL: https://doi.org/10.1038/s41430-020-0558-y.
  6. Haimi M., Kremer R. Vitamin D deficiency/insufficiency from childhood to adulthood: Insights from a sunny country. World J Clin Pediatr. 2017. Feb 8;6(1):1–9. DOI: 10.5409/wjcp.v6.i1.1. PMID: 28224090; PMCID: PMC5296623.
  7. Povorozniuk V.V., Pludovski P. Defitsyt ta nedostatnist vitaminu D: epidemiolohiia, diahnostyka, profilaktyka ta likuvannia. Donetsk: Vydavets Zaslavskyi O.Iu. 2014. 262 s. (in Ukrainian).
  8. Shchubelka K. Vitamin D status in adults and children in Transcarpathia, Ukraine in 2019. BMC Nutr6, 48 (2020). URL: https://doi.org/10.1186/s40795-020-00380-5.
  9. Kodentsova V.M., Mendel’ O.I., Khotimchenko S.A., et al. Physiological needs and effective doses of vitamin D for deficiency correction. Current state of the problem. Voprosy Pitaniia. 2017. 86(2):47–62. DOI: 10.24411/0042-8833-2017-00033. PMID: 30645878.
  10. Spiro A., Buttriss J.L. Vitamin D: An overview of vitamin D status and intake in Europe. Nutr Bull. 2014. Dec; 39(4):322–350. DOI: 10.1111/nbu.12108. PMID: 25635171; PMCID: PMC4288313. URL: https://doi.org/10.1111/nbu.12108.
  11. Povorozniuk V.V., Balatska N.I. Deficiency of vitamin D among Ukrainian population: risk-factors of development. REPRODUCTIVE ENDOCRINOLOGY, 2013. 13, 7–13. URL: https://doi.org/10.18370/2309-4117.2013.13.7-13.
  12. Shanyhin A. Hygienic assessment of the dependence of vitamin D levels and body mass index in residents of the southern region of Ukraine. In: International scientific conference New trends and unsolved issues in medicine. 2022. Jul 29–30. Riga, Latvia. URL: https://doi.org/10.30525/978-9934-26-226-5-78.
  13. Holick M.F., Binkley N.C., Bischoff-Ferrari H.A., Gordon C.M., Hanley D.A, Heaney R.P., Murad M.H., & Weaver C.M. Evaluation, treatment, and prevention of vitamin D deficiency. An Endocrine Society Clinical Practice Guideline. J. Clin. Endocrinol. Metab., 2011. 96 (7), 1911–1930.