The experimental researches are carried out on 160 male and female rats, which were exposed to continuous 4-day deprivation of dream. As a result of the conducted researches is established, that dream deprivation results in substantial growth of the adrenaline and noradrenaline contents in neuroendocrine structures of both male, and female. Manifestation of the revealed changes depend on time of the stressful factor action and sex of rats. In neuroendocrine structures of male rats more intensive increase of the catecholamine contents was observed, and their restoration up to a physiological level in a poststress period occurred faster in female rats.