Prospective study of 75 patients with severe brain injury who were conducted intracranial and cerebral perfusion pressure monitoring during decompressive craniectomy. DC with dura opening proved effective therapeutic method for ICP and CPP control. Unilateral wide frontal parieto-temporal craniectomy causes initial ICP value to fall from (39.0±18.1) mmHg to (15.8±12.4) mmHg (р<0.05) and CPT, to increase from (56.8±24.4) mmHg to (77.7±20.4) mmHg (р<0.05).