It was carried out comparative study of cationic and anionic porphyrins influence on Pseudomonas aeruginosa cells. It was determined that studied tetrapyrrols may depress the growth of antibiotic-resistant P. aeruginosa both in dark conditions and after irradiation. Anionic porphyrins have shown higher activity. Among cationic compounds more expressed suppressing effect free base had and among anionic — metal complex.