The results of indices of tuberculous mycobacteria resistance in Odessa and Odessa Region according to the retrospective survey are given. In total, in 2002 67.7 % of all isolates were resistant at least to one drugs, which 10.0% exceeds rates of 2000. The number of strains resistant to two or more drugs raised in 2002 as compared to 2000 by 2.1 times. In 2002, 37.8 %, 35.7 % and 22.4 % of all isolates were resistant to isoniazid, rifampicin and both drugs (multidrug resistant) respectively, which exceeds 2000 rates by 12.8 %, 16.2 % and 10.7 % respectively. The given data demonstrate constant worsening of epidemiological situation regarding drug resistant strains in the Odessa region.