It is shown that from the moment of the latent stage of the experimental glomerulonephritis the phosphoinositides metabolism rate and the phosphatidilinositol-4,5-biphosphate hydrolysis, the concentration of the inositiolphosphates in the nephrocytes cytoplasme and in the serum increase. The inositolphosphates concentration in the nephrocytes has positive correlation with the calcium and negative — with ATP.