The frequency of esophageal atresia among 469,832 newborns in Lviv region during 1985–2001 was 1,04±0,59 per 10,000 newborns. Trustworthy increasing of esophageal atresia in different periods in comparison with 1985–2001 was not detected. The fluctuation of frequency of this pathology had a wavy character. The lowest index of esophageal atresia frequency was observed in Mostysky (0,54 per 10,000 newborns, P<0,05) and in Zolochivsky (0,62 per 10,000 newborns, P<0,05) districts. The highest index was in Skolivsky (3,41 per 10,000 newborns, P<0,05) and in Drogobytsky (2,98 per 10000 newborns, P<0,05) districts and that had statistucally valued difference in comparison with the frequency for 1985–2001 in Lviv region.