Studying and clinical estimation of perinatal outcomes of 78 cases multiple gestations in women, which were delivered in the Kiev regional center of mother and newborn health-care in 2000–2003 were carried out. The newborns with low body-weight in multiple pregnancy was met 6 times more often, intrauterine restriction was revealed in 9 %, and intra-uterine dissociation — in 4.4 % of twins. As a whole, multiple gestations “have caused” 10.2 % of cumulative perinatal losses. Thus, intrauterine infection and hypoxia of a fetus have got greatest distribution. We consider it necesssary to carry out multi-center researches to put the existing clinical data in order, to develop precise algorithms of conducting gestation and labors in women with multiple pregnancy and improve the used techniques.