The article gives the modern understanding of etiology and pathogenesis of Buerger’s disease, which to date are still open and not cleared up finally. Among etiologic stimuli a leading place occupies consumption of tobacco. Thromboangiitis obliterans has an immunological genesis. There are two possible pathogenetic mechanisms of the disease. The autoimmune character of defeat of vessels is envisaged in the first case, in the second one — with participation of immune complexes.
