STUDY OF ANTIARRHYTHMIC PROPERTIES DERIVATIVES OF GERMANIUM BIPHOSPHONATES WITH BIOLIGANDS. Report 2

In this article there are results of the following up experiments dedicated to exploration of an antiarrhythmic activity of germanium derivative with magnesium MIGU-6. Thanks to the method of measuring of A2/A1 ratio it was proved that MIGU-6 has significant antiarrythmic activity. However, exploration of MIGU-6 influence on myogenic automatism with the help of registration of portal vein contraction in rats showed that given compound had significant effect on pace-maker activity, that manifestated by rhythm synchronization of secondary rhythm-driver with rhythm of basic frequency and respectively by normalization of contraction rhythm. Thus, the results testify that MIGU-6 can be considered as potential candidate for development of a new antiarrythmic agent.