Herpetic infection is one of the most spread uncontrolled human infections. The complex approach proposed in this paper was remarkably successful in treatment of recurrent herpes infection, which includes long-term suppression therapy with acyclovir, valtrex and individual prescription of immunomodulators. The prescription of immunomodulators against a background of the long-term therapy resulted in reduced duration of recurrences and in increasing of the interrecurrence periods. Prolonged suppressive antiviral therapy can reduce asymptomatic relapses.