In acute experiments on male Wistar rats it was shown that i.p. administration of human recombinant interferone 2-alpha (“Lapherone”) in a dose of 1,000,0 and 2,000,0 IU/kg was followed by decreasing of thiol groups content along with the concomitant increasing of disulfide groups in blood. Mentioned deteriorations were more pronounced in non-protein fraction of rat’s blood and were abolished by obzidan administration (10.0 mg/kg, i.p.), which being administered alone did not cause deteriorations in functional state of thiol-disulfide system of blood.
