Objective. Сomparative characteristics of the distribution of MIGU-1 and MIGU-4 and the determination of the central and peripheral chambers of the kinetic distribution scheme.
Materials and methods. After compounds intra-abdominal introduction to the “Vistar” line rat-males 140–150 g (at 37.5 mg/kg of germanium) in 0.25; 0.5; 1; 2; 4; 8; 24 hours blood plasma sampled, brain, liver, heart. Сoncentration of complexes was determined by the extraction-photometric method. Сhart of the ratio of the concentration of substances between blood plasma and other test tissues were constructed. The obtained graphs made it possible to characterize the presence of a simultaneous effect or its deformation.
Results. With the introduction of MIGU-4 concentration germanium between the blood plasma and brain, liver, rapid distribution (no hysteresis loop) is carried out, which indicates the rapid achievement of pharmacological effect, but with the introduction of MIGU-1 there is a hysteresis loop, which indicates a slow exchange between tissues, so the pharmacological effect may manifest much later. With the introduction of both BAS, the graph of the ratio of germanium content in the heart and blood plasma has a hysteresis loop, it is a slow exchange between the tissues, so the pharmacological effect may appear much later.
Conclusions. Studying the phenomenon of hysteresis made it possible in the brain, liver and heart to reveal the features and speed of the processes of distribution of BAS MIGU-1 and MIGU-2, to predict the time of onset of the pharmacological effect and side effects.