Objective. To evaluate the influence of lipid and carbohydrate metabolism on biological age (BА) and aging rates (AR) in the combined course of hypertension (H) and type 2 diabetes mellitus (DM2T) compared with isolated hypertension (IH) in elderly patients.
Materials and methods. Anthropometric indices, carbohydrate and lipid metabolism rates in 46 patients with IH stage II (1 group) and 105 patients with H II stage and DM2T (group 2) were studied according to standard methods. BA and AR parameters were investigated by the method of V. P. Voytenko et al.
Results. BA in group 2 was significantly different from group 1. AR indexes in group 2 varied more than in 1 group, reflecting the presence of premature aging signs. In patients with IH, physiological aging (FA) was found in 6 (13.04%), delayed AR (DAR) — in 23 (50.0%), accelerated AR (ARA) — in 17 (36.96%) patients. In group 2 FA was observed in 10 (9.52%), DAR — in 32 (30.48%), ARA — in 63 (60.0%) patients. Among group 2 patients those who subjectively evaluated their health status (HS) as satisfactory or good in comparison with those with unsatisfactory or bad HS had significally lower levels of proatherogenic lipids (p<0.05). The levels of fasting glucose in individuals with satisfactory HS was significantly lower, while HbA1c levels were practically unchanged (p>0.05).
Conclusion. In the elderly patients with H and DM2T, higher BA and more pronounced signs of premature aging were showed. Patients with H and DM2T with subjectively unsatisfactory HS had significantly more severe lipid metabolism disorders, whereas this association was unreliable for carbohydrate metabolism. Detection of connection between BA and lipid and carbohydrate metabolism parameters allows BA to be used not only for the assessment of the functional state of the body as a whole, but also for the assessment of cardio-vascular risk.