The lack of specific etiotropic therapy for measles virus makes vaccine prevention the most appropriate strategy for managing this infection. Modern live attenuated measles vaccines provide the formation of a strong immunity, but to ensure epidemic well-being and prevent the spread of infection among the population, vaccination should cover at least 95 %. Reduction of this indicator to 93% can lead to the development of epidemic outbreaks, which is now observed in Ukraine. Unreliable information about the possible risks of using vaccines in children leads to a decrease in the number of vaccinated people. In turn, this increases the possible number of infected, diseased. Therefore, WHO recommends improving both vaccine prevention measures and a laboratory service system to control the spread of this infection in order to achieve the global goal of eliminating measles as a whole.