Relevance. The need to establish the topography of cancer of the prostate due to the difference data of the lesion volume and extent of the process at the pre- and post-operative examination. This concerns the question whether the process is close to the capsule of the gland or the spread ofcancer has occurred beyond its limits. Intraoperative macro-assessment of the state of the surgical edge of the macropreparation of the remote pancreas is unreliable, intraoperative research on frozen sections is laborious and lengthy. The choice of the investigated area is random and subjective.

Purpose: improvement of pathological diagnostics of pancreatic cancer.

Methods: macro- and microscopic examination of the tissues of the pancreas, as well as methods: experimental, analytical, bibliosemantic, data transfer.

Results. A method was developed aimed at improving the determination of pancreatic cancer topography relative to the prostatic capsule at the preoperative stage. This method allows to assess the extent of the spread of the process, to decide on the preservation of the neurovascular bundles during radical prostatectomy. The technique of restoring the unity of the prostate microslide with the subsequent marking of resection edges has been improved. The method allows you to accurately determine the stage of cancer of the pancreas after surgery, to avoid errors regarding the definition of “positivity” of the resection edge, contributes to timely adjuvant therapy. The intraoperative evaluation of the surgical margin of the drug during radical prostatectomy in patients with locally advanced prostate cancer was improved, which increased the radical nature of the surgical procedure and improved the results of treatment.

Conclusions. 1. The study of this problem and the cooperation of the pathologist with the oncourologist contributed to the development of ways to:
— in establishing the topography of pancreatic cancer relative to the prostatic capsule at the preoperative stage;
— on reconstruction of the surgical region of the drug after radical prostatectomy in patients with locally advanced cancer of the pancreas;
— panoramic intraoperative study of surgical resection margin in radical prostatectomy.
2. The obtained data can be used to establish the management of treatment in accordance with the stage of the disease and the individual characteristics of the tumor and the body.