To study the effect of carbacetam on the system of nitric oxide and antioxidant protection in the hippocampus of rats with experimental Alzheimer’s disease. Experiments were performed on non-linear laboratory white rats in males weighing 0.18–0.20 kg. The Alzheimer’s disease model was created by intraabdominal administration of 27 days of scopolamine hydrochloride (Sigma, USA) at a dose of 1 mg/kg. From the 28th day of the experiment, carbacetam was administered intraperitoneally with a dose of 5 mg/kg in 1 ml of physiological saline — once a day, for 14 days. The content of stable metabolites of nitric oxide, NO-synthase, superoxide dismutase and catalase in the cytosolic fraction of the hippocampus was determined. Indicators of nitric oxide in Alzheimer’s rats after 14 days of administration of carbacetam were characterized by a decrease in NO2 content, NOS activity, an increase in catalase activity, and the normalization of superoxide dismutase. The obtained results indicate a corrective effect on the nitric oxide system and an increase of antioxidant protection under the action of carbacetam in the design of Alzheimer’s disease.
