Introduction. Arterial hypertension (AH) is the most important cardiovascular risk factor. However, the optimal time for drugs administration is still the subject of discussions.
Materials and methods. 57 patients with hypertension were examined. Patients were divided into three groups, depending on the regime of administration of antihypertensive drugs: group 1 — 1 time per day in the morning; group 2 — 1 time per day after 18.00; group 3 — 2 times daily. Patients underwent ambulatory blood pressure monitoring (ABPM). The ABPM data, AH clinical characteristics and pharmacotherapy parameters were evaluated.
Results. There were no statistically significant differences between the mean values of SBP and DBP in different monitoring periods between groups. In group 2, the majority of patients had a dipper type of daily SBP profile, and this percentage was the highest among the three groups. The average value of the number of antihypertensive drugs taken by one patient and the total dose factor were the lowest in group 2, and the highest in group 3 (p<0.05). The frequency of monotherapy was the highest in group 2.
Discussion. Evening regimen of antihypertensive drugs administration was more light in relation to drug load and more effective in relation to SBP daily profile normalisation.
Conclusions. Antihypertensive therapy helps to normalize blood pressure and reduce cardiovascular risk. Its success is achieved at different treatment regimens, but the best was the evening, both in relation to the medication load, and in relation to the normalization of the daily profile of blood pressure.