Objective: to study the indices of heart rate variability (HRV) in patients with primary mitral valve prolapse (MVP) depending on the daily profile of blood pressure (BP).
Materials and methods. The study included 25 women (mean age 27.5±7.2 years) and 19 men (mean age (25.5±6.3) years) with primary MVP. The first group consisted of patients with PMC with normal blood pressure (n=19). The second group (n=15) consisted of patients diagnosed with arterial hypertension (AH) of 1–2 degree (according to the history of blood pressure, they increased for 3–6 years) and confirmed during daily monitoring of blood pressure (BP). The diagnosis of MVP was established using Doppler echocardiography on the GE Logiq P5 Pro (USA). HRV of short ECG records was performed with the help of the automated diagnostic complex “Cardio +” (NPP Metekol, Ukraine). BP monitoring was performed in all patients (ABPM-04, Hungary).
Results and discussion. The time index of systolic and diastolic blood pressure in patients of the second group exceeded normative values and was significantly higher than in the first group (p<0.001). The variability of diastolic BP was significantly higher in patients in the second group (p<0.01). The total HRV power, that is, the power of the effect of neurohumoral regulation in patients of the second group exceeded that of the patients of the first group. When comparing the spectral analysis at rest in patients of the second group, VLF values significantly exceeded the corresponding indices in patients of the first group (p=0.021). The index of vagosympathetic interaction of LF/HF in patients of the second group was on average 4.4% higher than in the patients of the first group, and also the activity of parasympathetic influence decreased simultaneously.
Conclusions. In patients of the second group, the presence of reliable interrelations between changes in the daily profile of blood pressure and the violation of autonomic regulation of cardiovascular functions in the form of an increase in the power of the LF component of the spectrum (LF, LFn), a significant increase in the vagosympathetic coefficient and total spectrum power.