The condition of immune and hemostasis systems was examined in patients suffering from atopic dermatitis. 66 patients had changes in cellular and humoral components of immune system, factors of a nonspecific resistance of an organism, and also, parameters of hemostasis system testifying to a tendency to hypercoagulation. The drugs protephlazid and trental which have rendered promoted immunomodulating and hypocoagulating action were used for correction of revealed changes in patients suffering from atopic dermatitis.