It has been shown in research оn 42 nonlinear albino male rats bу vegetative resonance test “Imedis-test+” method, that increase of vasoconstrictory, collagen-stimulating tromboxan А2 factors, angiotensin 2 and proinflammatory interleukins lβ, 4, interferon γ in renal cortex at chronic Mazugi nephritis is accompanied bу active inflammatory process and increased content of collagen marker oxyproline with development of tubules atrophic process due to proapoptotic protein р53 growth.